Eaton R P, Spencer W, Schade D S, Shafer B D, Corbett W
Diabetes Care. 1978 Jan-Feb;1(1):40-4. doi: 10.2337/diacare.1.1.40.
Optimal management of the diabetic patient includes normalization of plasma glucose concentration. Attainment of this goal is difficult because both food and stress result in acute elevations of blood glucose that cannot be matched with a single subcutaneous injection of NPH insulin. This paper examines the currently available methods for delivery of insulin to the diabetic subject and the degree of metabolic control attained. It suggests that optimal diabetic control will be achieved only when newer methods of insulin delivery are available to the clinician that match plasma insulin requirements to the simultaneous plasma glucose concentration.
糖尿病患者的最佳管理包括使血浆葡萄糖浓度正常化。实现这一目标很困难，因为食物和应激都会导致血糖急性升高，而单次皮下注射中性鱼精蛋白锌胰岛素（NPH胰岛素）无法与之匹配。本文研究了目前可用于向糖尿病患者输送胰岛素的方法以及所达到的代谢控制程度。它表明，只有当临床医生能够使用将血浆胰岛素需求与同时的血浆葡萄糖浓度相匹配的新型胰岛素输送方法时，才能实现最佳的糖尿病控制。
