Schade D S, Eaton R P, Friedman N M, Spencer W J
Diabetologia. 1980 Jul;19(1):35-9. doi: 10.1007/BF00258308.
This study examined the feasibility of normalizing the plasma insulin profile in five insulin deficient diabetic males. Acute meal-related increases in plasma free insulin concentration were achieved by administering short-acting insulin intraperitoneally with a pre-programmed portable rotary splenoid driven pump. This insulin response was compared to that achieved when short-acting insulin was injected subcutaneously 15 minutes prior to each meal. After intraperitoneal insulin maximal plasma free insulin concentration was observed within 45 minutes of administration, and averaged 40 +/- 13 mU/l(+/- SEM) for breakfast, 30 +/- 13 mU/l for lunch, and 36 +/- 13 mU/l for supper. This acute rise was followed by a gradual decline in plasma free insulin concentration, simulating a normal plasma insulin profile. With subcutaneously injected insulin, approximately the same maximal plasma free insulin concentration was obtained as observed with intraperitoneal insulin, but it was delayed 116 minutes following injection. These data suggest that intraperitoneally delivered insulin is rapidly absorbed and may normalize the peripheral plasma free insulin concentration, at least during short-term studies.
本研究检测了使5名胰岛素缺乏型糖尿病男性的血浆胰岛素谱正常化的可行性。通过使用预编程的便携式旋转脾脏驱动泵腹腔内注射短效胰岛素，实现了与进餐相关的血浆游离胰岛素浓度的急性升高。将这种胰岛素反应与每餐饭前15分钟皮下注射短效胰岛素时的反应进行比较。腹腔内注射胰岛素后，在给药后45分钟内观察到最大血浆游离胰岛素浓度，早餐时平均为40±13 mU/l（±标准误），午餐时为30±13 mU/l，晚餐时为36±13 mU/l。这种急性升高之后，血浆游离胰岛素浓度逐渐下降，模拟了正常的血浆胰岛素谱。皮下注射胰岛素时，获得的最大血浆游离胰岛素浓度与腹腔内注射胰岛素时观察到的大致相同，但注射后延迟了116分钟。这些数据表明，腹腔内注射的胰岛素吸收迅速，至少在短期研究中可能使外周血浆游离胰岛素浓度正常化。
