降低中国血脂异常人群心血管代谢疾病风险的饮食模式：一项单中心、开放标签、随机饮食干预研究。

Reducing cardiometabolic disease risk dietary pattern in the Chinese population with dyslipidemia: a single-center, open-label, randomized, dietary intervention study.

作者信息

Wu Qi, Bian Shanshan, Cheng Cheng, Chen Xukun, Zhang Liyang, Huang Li, Li Tongtong, Yan Ruiting, Duan Huilian, Wang Zehao, Li Yuan, Wu Tongyang, Wang Yue, Chen Yan, Deng Xiping, Chen Yongjie, Zhang Meilin, Ma Fei, Li Wen, Huang Guowei

机构信息

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.

Nutrition Department, The Second Hospital of Tianjin Medical University, Tianjin, China.

出版信息

Am J Clin Nutr. 2025 May;121(5):1035-1045. doi: 10.1016/j.ajcnut.2025.02.026. Epub 2025 Feb 25.

DOI:10.1016/j.ajcnut.2025.02.026

PMID:40015682

Abstract

BACKGROUND

There is no specific dietary pattern for cardiometabolic health based on Chinese food culture.

OBJECTIVES

The study aimed to develop and assess the efficacy of the reducing cardiometabolic disease risk (RCMDR) dietary pattern on cardiometabolic disease risk in the Chinese population with dyslipidemia.

METHODS

In this single-center, open-label, randomized, 12-wk dietary intervention study, 100 adults aged 35-45 y with dyslipidemia were randomly assigned (1:1) to the RCMDR dietary pattern intervention or general health education control group.

RESULTS

Compared with the control group, the RCMDR dietary pattern intervention resulted in a significantly lower clustered cardiometabolic risk score (primary outcome) (β: -0.17; 95% CI: -0.29, -0.05); diastolic blood pressure (β: -0.23; 95% CI: -0.40, -0.07); total cholesterol, LDL cholesterol, triglyceride (β: -0.27; 95% CI: -0.49, -0.04; β: -0.24; 95% CI: -0.41, -0.07; and β: -0.19; 95% CI: -0.35, -0.04, respectively); homocysteine (β: -0.19; 95% CI: -0.28, -0.09); waist circumference, waist-to-hip ratio, body fat percentage, body fat mass, visceral adipose tissue, visceral fat area, and a significantly higher lean body mass (β: -1.12; 95% CI: -1.65, -0.59; β: -1.01; 95% CI: -1.66, -0.36; β: -1.43; 95% CI: -1.87, -0.98; β: -0.98; 95% CI: -1.35, -0.60; β: -1.93; 95% CI: -2.75, -1.11; β: -6.52; 95% CI: -9.10, -3.95; and β: 1.24; 95% CI: 0.84, 1.65, respectively).

CONCLUSIONS

Compared with the control group, the RCMDR dietary pattern intervention lowers cardiometabolic risk, blood lipids, blood pressure, abdominal obesity, and circulating homocysteine concentration among Chinese population with dyslipidemia.

CLINICAL TRIAL REGISTRY

This trial was registered at Chinese Clinical Trial Registry as ChiCTR2300072472 (https://www.chictr.org.cn/showproj.html?proj=198618).

摘要

背景

基于中国饮食文化，尚无针对心脏代谢健康的特定饮食模式。

目的

本研究旨在开发降低心脏代谢疾病风险（RCMDR）饮食模式，并评估其对中国血脂异常人群心脏代谢疾病风险的疗效。

方法

在这项单中心、开放标签、随机、为期12周的饮食干预研究中，100名年龄在35 - 45岁的血脂异常成年人被随机（1:1）分配至RCMDR饮食模式干预组或一般健康教育对照组。

结果

与对照组相比，RCMDR饮食模式干预使聚集性心脏代谢风险评分（主要结局）显著降低（β：-0.17；95%置信区间：-0.29，-0.05）；舒张压（β：-0.23；95%置信区间：-0.40，-0.07）；总胆固醇、低密度脂蛋白胆固醇、甘油三酯（β分别为：-0.27；95%置信区间：-0.49，-0.04；β：-0.24；95%置信区间：-0.41，-0.07；以及β：-0.19；95%置信区间：-0.35，-0.04）；同型半胱氨酸（β：-0.19；95%置信区间：-0.28，-0.09）；腰围、腰臀比、体脂百分比、体脂质量、内脏脂肪组织、内脏脂肪面积显著降低，而瘦体重显著增加（β分别为：-1.12；95%置信区间：-1.65，-0.59；β：-1.01；95%置信区间：-1.66，-0.36；β：-1.43；95%置信区间：-1.87，-0.98；β：-0.98；95%置信区间：-1.35，-0.60；β：-1.93；95%置信区间：-2.75，-1.11；β：-6.52；95%置信区间：-9.10，-3.95；以及β：1.24；95%置信区间：0.84，1.65）。