Andrejic Nikola, Božovic Ivo, Moradi Hadi, Tataei Rojin, Knezevic Nebojsa Nick
Advocate Illinois Masonic Medical Center, Department of Anesthesiology, Chicago, IL, USA.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Expert Opin Investig Drugs. 2025 Apr;34(4):287-299. doi: 10.1080/13543784.2025.2473692. Epub 2025 Mar 2.
Neuropathic pain (NP) remains a significant challenge in clinical practice, requiring a sophisticated pharmacotherapeutic strategy for effective symptom management. This review provides a comprehensive analysis of the current pharmacological treatments for NP, focusing on their efficacy, mechanism of action, and therapeutic potential. Additionally, it evaluates ongoing clinical trials investigating novel drugs and therapeutic approaches, highlighting emerging trends and future directions in NP management.
This review examines first- to third-line therapeutic modalities for NP, critically analyzing their efficacy, safety profiles, and clinical applications. It also includes an overview of ongoing clinical trials exploring innovative pharmacological therapies. A thorough literature review was conducted using the MEDLINE database without temporal limitations, offering a detailed assessment of established and emerging treatments.
While current pharmacological options offer significant symptom relief, their overall effectiveness in managing NP remains limited, highlighting the need for further therapeutic advancements. Staying informed about emerging therapies and clinical trials is vital to enhancing patient care and quality of life. The future of NP management lies in optimizing individualized treatment strategies, refining therapeutic approaches, and fostering interdisciplinary collaboration. Close monitoring of outcomes and continued research are essential for advancing understanding and improving the precision of NP therapies.
神经性疼痛（NP）在临床实践中仍然是一个重大挑战，需要复杂的药物治疗策略来有效管理症状。本综述对目前NP的药物治疗进行了全面分析，重点关注其疗效、作用机制和治疗潜力。此外，还评估了正在进行的研究新药和治疗方法的临床试验，突出了NP管理中的新趋势和未来方向。
本综述研究了NP的一线至三线治疗方式，批判性地分析了它们的疗效、安全性概况和临床应用。还包括对探索创新药物疗法的正在进行的临床试验的概述。使用MEDLINE数据库进行了不受时间限制的全面文献综述，对既定和新兴治疗方法进行了详细评估。
虽然目前的药物选择能显著缓解症状，但它们在管理NP方面的总体效果仍然有限，这突出了进一步治疗进展的必要性。了解新兴疗法和临床试验对于提高患者护理和生活质量至关重要。NP管理的未来在于优化个性化治疗策略、完善治疗方法以及促进跨学科合作。密切监测结果和持续研究对于增进理解和提高NP治疗的精准度至关重要。
