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芬顿生长曲线法预测孕36周及以前出生新生儿出生体重的可靠性。

Reliability of the Fenton growth curve method in predicting birth weight in newborns born at or before 36 weeks gestational age.

作者信息

Gungor Sara, Hou Wei, Decristofaro Joseph, Maduekwe Echezona T

机构信息

Department of Pediatrics, Neonatology, Stony Brook Children's Hospital, Stony Brook, NY, United States.

Family, Population and Preventive Medicine, Stony Brook Children's Hospital, Stony Brook, NY, United States.

出版信息

Front Pediatr. 2025 Feb 13;13:1482823. doi: 10.3389/fped.2025.1482823. eCollection 2025.

Abstract

OBJECTIVES

The study aimed to assess the reliability of the Fenton curve superimposed with fetal weight percentile in predicting the birth weight of infants born ≤36 weeks gestational age.

STUDY DESIGN

This prospective observational study, conducted from December 2018 to May 2019, examined infants born ≤36 weeks gestational age. The Fenton curve was used to extrapolate the fetal growth percentile (Fenton curve method) and predict the birth weight of the infants on the day of delivery. The study excluded infants who were large or small for gestational age and those diagnosed with congenital anomalies or Hydrops fetalis. The Fenton curve method was used to predict the actual birth weight of 65 infants born at Stony Brook University Hospital and was compared with their actual birth weight using a two-sample -test and Bland-Altman test.

RESULTS

The study enrolled 65 infants, including 37 females, 2 Asians, 6 Blacks, 17 Hispanics, and 40 whites, with a mean gestational age of 32.1 ± 3.6 weeks and a mean actual birth weight of 1,860 ± 677 grams. The results showed no significant difference between the predicted and actual birth weight ( = 0.17), with a median difference of 32.2 grams between the predicted and actual weight.

CONCLUSION

The study found that the Fenton curve method reliably predicted the birth weight of infants born ≤36 weeks of gestational age. The results indicate that in normally grown fetuses, healthcare providers in the delivery room could potentially use Fenton curve predicted birth weight for drug dosage and equipment sizing in scenarios where obtaining actual birth weight is not possible. Nonetheless, additional analysis in larger cohorts is needed before this method can be universally adopted.

摘要

目的

本研究旨在评估叠加胎儿体重百分位数的芬顿曲线在预测孕周≤36周出生婴儿出生体重方面的可靠性。

研究设计

这项前瞻性观察性研究于2018年12月至2019年5月进行,研究对象为孕周≤36周出生的婴儿。使用芬顿曲线推算胎儿生长百分位数(芬顿曲线法)并预测分娩日婴儿的出生体重。该研究排除了大于或小于孕周的婴儿以及诊断为先天性异常或胎儿水肿的婴儿。采用芬顿曲线法预测了65名在石溪大学医院出生的婴儿的实际出生体重,并使用双样本检验和布兰德-奥特曼检验将其与实际出生体重进行比较。

结果

该研究纳入了65名婴儿,其中包括37名女性、2名亚洲人、6名黑人、17名西班牙裔和40名白人,平均孕周为32.1±3.6周,平均实际出生体重为1860±677克。结果显示预测出生体重与实际出生体重之间无显著差异(P=0.17),预测体重与实际体重的中位数差异为32.2克。

结论

该研究发现芬顿曲线法能够可靠地预测孕周≤36周出生婴儿的出生体重。结果表明,在正常生长的胎儿中,产房的医护人员在无法获得实际出生体重的情况下,可能会使用芬顿曲线预测的出生体重来确定药物剂量和设备尺寸。尽管如此,在该方法能够被普遍采用之前,还需要在更大的队列中进行进一步分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5d3/11865019/39db0d2e107a/fped-13-1482823-g001.jpg

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