Latt Phyu Mon, Soe Nyi Nyi, Xu Xianglong, Rahman Rashidur, Chow Eric P F, Ong Jason J, Fairley Christopher, Zhang Lei
Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia.
BMJ Public Health. 2023 Aug 23;1(1):e000012. doi: 10.1136/bmjph-2023-000012. eCollection 2023 Nov.
The risk of HIV and sexually transmitted infections (STIs) varies substantially across population groups in Australia. We examined this disparity in HIV/STI distribution using Gini coefficients, where scores closer to one indicate greater disparity.
We used demographic and sexual behaviour data from the Melbourne Sexual Health Centre, between 2015 and 2018. We examined 88 642 HIV consultations, 92 291 syphilis consultations, 97 473 gonorrhoea consultations and 115 845 chlamydia consultations. We applied a machine learning-based risk assessment tool, MySTIRisk, to determine the risk scores. Based on individuals' risk scores and HIV/STIs diagnoses, we calculated the Gini coefficients for these infections for different subgroups.
Overall, Gini coefficients were highest for syphilis (0.60, 95% CI 0.57 to 0.64) followed by HIV (0.57, 95% CI 0.52 to 0.62), gonorrhoea (0.38, 95% CI 0.36 to 0.42) and chlamydia (0.31, 95% CI 0.28 to 0.35). Gay, bisexual and other men who have sex with men (GBMSM) had lower Gini coefficients compared with heterosexual men or women; HIV (0.54 vs 0.94 vs 0.96), syphilis (0.50 vs 0.86 vs 0.93), gonorrhoea (0.24 vs 0.57 vs 0.57) and chlamydia (0.23 vs 0.42 vs 0.40), respectively. The Gini coefficient was lower among 25-34 years than in other age groups for HIV (0.66 vs 0.83-0.90) and gonorrhoea (0.38 vs 0.43-0.47). For syphilis, the oldest age group (≥45 years) had a lower Gini coefficient than 18-24 years (0.61 vs 0.70).
Our study demonstrated that HIV/STIs are more evenly distributed among GBMSM, suggesting widely disseminated interventions for GBMSM communities. In contrast, interventions for heterosexual men and women should be more targeted at individuals with higher risk scores.
在澳大利亚,不同人群感染艾滋病毒和性传播感染(STIs)的风险差异很大。我们使用基尼系数研究了艾滋病毒/性传播感染分布的这种差异,其中分数越接近1表示差异越大。
我们使用了2015年至2018年间墨尔本性健康中心的人口统计学和性行为数据。我们研究了88642例艾滋病毒咨询、92291例梅毒咨询、97473例淋病咨询和115845例衣原体咨询。我们应用了一种基于机器学习的风险评估工具MySTIRisk来确定风险分数。根据个体的风险分数和艾滋病毒/性传播感染诊断结果,我们计算了不同亚组这些感染的基尼系数。
总体而言,梅毒的基尼系数最高(0.60,95%可信区间0.57至0.64),其次是艾滋病毒(0.57,95%可信区间0.52至0.62)、淋病(0.38,95%可信区间0.36至0.42)和衣原体(0.31,95%可信区间0.28至0.35)。男同性恋、双性恋和其他与男性发生性关系的男性(GBMSM)的基尼系数低于异性恋男性或女性;艾滋病毒(0.54对0.94对0.96)、梅毒(0.50对0.86对0.93)、淋病(0.24对0.57对0.57)和衣原体(0.23对0.42对0.40)。对于艾滋病毒(0.66对0.83 - 0.90)和淋病(0.38对0.43 - 0.47),25 - 34岁年龄组的基尼系数低于其他年龄组。对于梅毒,年龄最大的年龄组(≥45岁)的基尼系数低于18 - 24岁年龄组(0.61对0.70)。
我们的研究表明,艾滋病毒/性传播感染在男同性恋、双性恋和其他与男性发生性关系的男性中分布更为均匀,这表明应针对该群体广泛开展干预措施。相比之下,针对异性恋男性和女性的干预措施应更有针对性地针对风险分数较高的个体。