Murashov B F, Osadchuk M A
Ter Arkh. 1985;57(2):40-3.
The metabolism of collagen and glycoproteins bound with glycosaminoglycans was studied in 19 patients with a preulcerous condition (chronic primary gastroduodenitis) and in 49 patients with peptic ulcer of the stomach (12) and duodenum (37). The control groups comprised 12 practically healthy subjects (group I) and 20 patients with chronic secondary gastroduodenitis (group II). Based on the data obtained it is concluded that the high level of collagen metabolism in patients with chronic gastroduodenitis may be regarded as an early diagnostic criterion of the preulcerous condition. In patients with peptic ulcer, epithelization of the peptic defect controlled with the aid of studying the indicators of collagen formation should not be viewed as completed after clinico-endoscopic confirmation of the disease remission. There was a close correlation between the ulcerous crater area and the level of free hydroxyproline in gastric juice. High level of glycoproteins in patients with gastroduodenitis and peptic ulcer can be used as an additional criterion of the degree of the inflammatory reaction.
对19例患有溃疡前期疾病（慢性原发性胃十二指肠炎症）的患者以及49例患有胃溃疡（12例）和十二指肠溃疡（37例）的患者，研究了与糖胺聚糖结合的胶原蛋白和糖蛋白的代谢情况。对照组包括12名实际健康的受试者（第一组）和20例患有慢性继发性胃十二指肠炎症的患者（第二组）。根据所获得的数据得出结论，慢性胃十二指肠炎症患者胶原蛋白代谢水平较高可被视为溃疡前期疾病的早期诊断标准。对于患有消化性溃疡的患者，借助研究胶原蛋白形成指标来控制消化性缺损的上皮化，在临床内镜确认疾病缓解后，不应视为已完成。溃疡 crater 面积与胃液中游离羟脯氨酸水平之间存在密切相关性。胃十二指肠炎症和消化性溃疡患者糖蛋白水平较高，可作为炎症反应程度的附加标准。
