DeLuca V A, Winnan G G, Sheahan D G, Sanders F J, Greenlaw R, Marignani P, Gorelick F S, Bhalotra R, Goldblatt R S
J Clin Gastroenterol. 1981;3(Suppl 2):17-22.
Gastroduodenitis should be included with duodenal ulcer and gastric ulcer in the spectrum of clinical disorders that have different pathogenetic mechanisms but a similar clinical picture. Published results of a clinical, endoscopic, radiologic, and histologic study of 100 patients presenting with gastrointestinal symptoms revealed that 61% had classic and 39% had atypical manifestations of peptic ulcer disease. We could not clinically distinguish the 24 patients with ulcer crater (40% of the classic group) from the 25 patients with acute gastroduodenitis without crater (41% of the classic group). Preliminary data of a prospective study compared the treatment responses of 19 patients with gastroduodenitis and 39 patients with peptic ulcer disease. These patients were diagnosed endoscopically and restudied after treatment with a bland diet and antacids seven times per day for 8 weeks. The responses to therapy in gastroduodenitis and peptic ulcer were as follows: endoscopically, 63 and 80%, respectively; histologically, 74 and 65%, respectively; symptomatically, 47 and 65%, respectively. Preliminary data on the duodenal epithelial thymidine uptake revealed an increased proliferative index in duodenitis patients but not in patients with peptic ulcer or control subjects.
胃十二指肠炎症应与十二指肠溃疡和胃溃疡一同纳入临床疾病范畴，这些疾病虽发病机制不同，但临床表现相似。一项针对100例有胃肠道症状患者的临床、内镜、放射学及组织学研究结果显示，61%的患者有消化性溃疡病的典型表现，39%有非典型表现。我们在临床上无法区分24例有溃疡龛影的患者（占典型组的40%）与25例无龛影的急性胃十二指肠炎症患者（占典型组的41%）。一项前瞻性研究的初步数据比较了19例胃十二指肠炎症患者和39例消化性溃疡病患者的治疗反应。这些患者经内镜诊断，并在接受每天7次的清淡饮食和抗酸剂治疗8周后再次接受检查。胃十二指肠炎症和消化性溃疡对治疗的反应如下：内镜检查方面，分别为63%和80%；组织学方面，分别为74%和65%；症状方面，分别为47%和65%。关于十二指肠上皮胸腺嘧啶摄取的初步数据显示，十二指肠炎症患者的增殖指数升高，而消化性溃疡患者及对照受试者则未升高。
