Chattopadhyay G, Basu K, Mukherjee S, Hazra B R
Medical College Hospital, Calcutta, India.
Trop Gastroenterol. 1997 Oct-Dec;18(4):156-9.
This study aimed to assess the prevalence of endoscopic and histological gastroduodenitis as well as helicobacter-like organisms in patients with peptic ulcer. After diagnostic endoscopy, gastroduodenal biopsy specimens were taken from thirty patients (n = 30) with clinical and endoscopic diagnosis of peptic ulcer (duodenal ulcer = 25, gastric ulcer = 5). Endoscopic gastroduodenitis occurred in 18 patients (60%). Histological gastritis was detected in the gastric body or antrum in 25 (83%) and duodenitis in 17 (57%) patients. There was significant correlation between endoscopic and histological gastritis (p < 0.05). Helicobacter-like organisms occurred in 73% of the patients with peptic ulcer and in 88% of the antral biopsy specimens showing antral gastritis. Presence of helicobacter-like organisms was in particular associated with acute on chronic gastritis compared to chronic gastritis (p < 0.01). Moreover the patients with gastritis were found to belong to the older age group and 81.8% had blood group O +ve (p < 0.01 and p < 0.05 respectively). We conclude that presence of helicobacter-like organisms in patients with peptic ulcer is significantly associated with acute on chronic gastritis.
本研究旨在评估消化性溃疡患者内镜下和组织学上的胃十二指肠炎症以及螺旋杆菌样微生物的患病率。在诊断性内镜检查后，从30例临床和内镜诊断为消化性溃疡的患者（n = 30）（十二指肠溃疡 = 25例，胃溃疡 = 5例）中获取胃十二指肠活检标本。18例患者（60%）出现内镜下胃十二指肠炎症。25例（83%）患者在胃体或胃窦检测到组织学胃炎，17例（57%）患者检测到十二指肠炎症。内镜下胃炎与组织学胃炎之间存在显著相关性（p < 0.05）。螺旋杆菌样微生物在73%的消化性溃疡患者以及88%显示胃窦胃炎的胃窦活检标本中出现。与慢性胃炎相比，螺旋杆菌样微生物的存在尤其与慢性复发性胃炎相关（p < 0.01）。此外，发现胃炎患者属于老年组，81.8%为O +ve血型（分别为p < 0.01和p < 0.05）。我们得出结论，消化性溃疡患者中螺旋杆菌样微生物的存在与慢性复发性胃炎显著相关。
