Todoroki Yasuyuki, Nakayamada Shingo, Miyagawa Ippei, Kubo Satoshi, Yoshioka Kiyotake, Satoh Minoru, Tanaka Yoshiya
First Department of Internal Medicine, University of Occupational and Environmental Health, Japan.
Department of Molecular Targeted Therapies (DMTT), School of Medicine, University of Occupational and Environmental Health, Japan.
Intern Med. 2025 Sep 1;64(17):2657-2662. doi: 10.2169/internalmedicine.4852-24. Epub 2025 Mar 1.
Anti-synthetase syndrome (ASyS) is a subset of idiopathic inflammatory myopathies characterized by a triad of myositis, interstitial lung disease, and arthritis. Patients with ASyS are generally treated with glucocorticoids, immunosuppressants, or both. We encountered a 53-year-old woman who developed anti-OJ autoantibodies-positive anti-synthetase syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and CoV-2 messenger RNA (mRNA) vaccination. Her dyspnea and rash resolved within 4 weeks of the initial examination, achieving spontaneous remission without treatment 52 weeks after the diagnosis. This case suggests a potential association between SARS-CoV-2 infection, mRNA vaccination, and the transient development of anti-OJ antibodies-positive ASyS.
抗合成酶综合征（ASyS）是特发性炎性肌病的一个亚型，其特征为肌炎、间质性肺病和关节炎三联征。ASyS患者通常采用糖皮质激素、免疫抑制剂或两者联合治疗。我们遇到一名53岁女性，在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）并接种SARS-CoV-2信使核糖核酸（mRNA）疫苗后，出现抗OJ自身抗体阳性的抗合成酶综合征。她的呼吸困难和皮疹在初次检查后4周内消退，诊断后52周未经治疗实现自发缓解。该病例提示SARS-CoV-2感染、mRNA疫苗接种与抗OJ抗体阳性ASyS的短暂发生之间可能存在关联。
