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抗体疗法中的综合多方面方法:针对肠道微生物群失调和胃肠道致癌细胞。

Comprehensive multifaceted approach in antibody therapeutics: targeting gut dysbiosis and gastrointestinal oncogenic cells.

作者信息

Guha Uddipta

机构信息

St Xaviers College (Autonomous) Kolkata Dept Microbiology, Kolkata, India.

出版信息

Inflammopharmacology. 2025 Mar;33(3):1331-1336. doi: 10.1007/s10787-025-01689-y. Epub 2025 Mar 2.

DOI:10.1007/s10787-025-01689-y
PMID:40025352
Abstract

Treatment of biomedicine has advanced significantly in recent years, and it now has a very high success rate with severity of side effects making it so much more compelling to study emerging treatments. A broad concept is proposed, which pools in nominal antibiotics administration nutrition nutritional supplement if requisite and antibodies by maximizing the potential synergy of these elements, that is where conventional methods stop, this paradigm shift starts. The antibiotics act on the pathogen alone and when combined with therapeutic techniques results in increased recovery along with proper body defenses. The first-ever study of its kind combines antibody complex disguising as a carrier for the drugs which improves the palatability, extend retention in body and makes easy to store as well as distribute. This ground-breaking method could really alter the way digestive diseases is treated and provide an alternative to conventional methods.

摘要

近年来,生物医学治疗取得了显著进展,目前成功率很高,副作用严重程度使得研究新兴治疗方法更具吸引力。提出了一个广泛的概念,即在必要时将名义上的抗生素给药、营养补充剂和抗体结合起来,通过最大化这些元素的潜在协同作用,传统方法到此为止,而这种范式转变由此开始。抗生素单独作用于病原体,与治疗技术结合时可提高康复率,并增强身体的防御能力。有史以来第一项此类研究将抗体复合物伪装成药物载体,这提高了适口性,延长了在体内的保留时间,便于储存和分发。这种开创性的方法真的可能会改变消化系统疾病的治疗方式,并为传统方法提供一种替代方案。

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Inflammopharmacology. 2025 Mar;33(3):1331-1336. doi: 10.1007/s10787-025-01689-y. Epub 2025 Mar 2.
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本文引用的文献

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Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review.口腔和肠道微生物群失调与牙周炎:系统性影响及其与胃肠道癌症的关联:综述。
Medicina (Kaunas). 2024 Aug 29;60(9):1416. doi: 10.3390/medicina60091416.
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The Effect of Thickened Water on Ciprofloxacin Pharmacokinetics: A Comparative Study in Adult Males.增稠水对环丙沙星药代动力学的影响:成年男性的一项对比研究。
J Clin Med. 2024 Aug 5;13(15):4573. doi: 10.3390/jcm13154573.
3
Gut Microbiota and Inflammation Modulation in a Rat Model for Ulcerative Colitis after the Intraperitoneal Administration of Apigenin, Luteolin, and Xanthohumol.
肠内微生物群和黄酮,木犀草素和黄腐酚对溃疡性结肠炎大鼠模型腹腔内给药后的炎症调节作用。
Int J Mol Sci. 2024 Mar 12;25(6):3236. doi: 10.3390/ijms25063236.
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A Comprehensive Review of the Effect of Honey on Human Health.蜂蜜对人类健康影响的综合评价
Nutrients. 2023 Jul 6;15(13):3056. doi: 10.3390/nu15133056.
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Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer.减毒沙门氏菌增强了结直肠癌临床前模型中 PD-L1 阻断免疫疗法的效果。
Front Immunol. 2022 Dec 20;13:1017780. doi: 10.3389/fimmu.2022.1017780. eCollection 2022.
6
The Potential of Honey as a Prebiotic Food to Re-engineer the Gut Microbiome Toward a Healthy State.蜂蜜作为益生元食品使肠道微生物群重塑为健康状态的潜力。
Front Nutr. 2022 Jul 28;9:957932. doi: 10.3389/fnut.2022.957932. eCollection 2022.
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J Food Sci. 2021 Sep;86(9):3778-3797. doi: 10.1111/1750-3841.15854. Epub 2021 Aug 1.
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Nutr Res Rev. 2020 Jun;33(1):50-76. doi: 10.1017/S0954422419000192. Epub 2019 Dec 3.
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