Clinic of Dental and Oral Pathology, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Eivenių Str. 2, LT-50161 Kaunas, Lithuania.
Medicina (Kaunas). 2024 Aug 29;60(9):1416. doi: 10.3390/medicina60091416.
Periodontitis can disrupt oral and gut microbiota, leading to dysbiosis that affects overall systemic health. Besides the spread of periodontal pathogens by the hematogenous route, they can also be translocated into the gastrointestinal tract, possibly intervening in the neoplastic process in the gastrointestinal tract. This manuscript reviews the relationship between oral and gut microbiota due to periodontitis, discussing systemic health implications and potential links to gastrointestinal cancer. This article highlights the significance and effect of dysbiosis in the gut, emphasizing the importance of maintaining oral health to prevent systemic diseases. Lastly, it will go through therapeutic innovations such as probiotics and oral microbiota analysis tools for systemic disease detection. These findings will mark the integration of oral health management in clinical practice to lower systemic disease risk and improve overall patient outcomes. : This manuscript aims to unravel the pathological interaction between oral and gut microbiota and their bidirectional effect on systemic diseases. : The review was performed using the MEDLINE and ScienceDirect databases. Reviewed articles were published in English between the year 2015 and 2024. The search used keywords such as ("oral microbiota" AND "periodontal disease") OR ("oral microbiota" AND "gastrointestinal cancer") OR ("Porphyromonas gingivalis" AND "periodontal disease") OR ("Helicobacter pylori" AND "gastric cancer") OR ("gut microbiome" AND "inflammatory bowel disease") OR ("oral microbiome" AND "systemic diseases"). : The dysbiotic change in the oral cavity due to periodontitis is linked directly and indirectly to systemic diseases such as IBS, neurodegenerative diseases, muscle joint diseases, respiratory infections, and gastrointestinal cancer; this underscores the importance of maintaining oral hygiene for prophylaxis of oral diseases and the prevention of systemic diseases. A better understanding of the interconnections between oral health and systemic diseases will integrate oral health management to offer new prevention, diagnostic, and treatment opportunities to improve overall patient outcomes.
牙周炎可破坏口腔和肠道微生物群，导致生态失调，影响整体全身健康。除了牙周病原体通过血流传播，它们还可以易位到胃肠道中，可能干预胃肠道的肿瘤发生过程。本文综述了牙周炎引起的口腔和肠道微生物群之间的关系，讨论了对全身健康的影响以及与胃肠道癌症的潜在联系。本文强调了肠道中生态失调的重要性和影响，强调保持口腔健康以预防全身疾病的重要性。最后，将探讨益生菌和口腔微生物组分析工具等治疗创新，以用于系统性疾病检测。这些发现将标志着将口腔健康管理纳入临床实践，以降低系统性疾病风险并改善整体患者结局。
本文旨在揭示口腔和肠道微生物群之间的病理相互作用及其对系统性疾病的双向影响。
使用 MEDLINE 和 ScienceDirect 数据库进行了综述。综述文章发表于 2015 年至 2024 年期间的英文期刊。使用的关键词搜索包括“口腔微生物群”和“牙周病”或“口腔微生物群”和“胃肠道癌症”或“牙龈卟啉单胞菌”和“牙周病”或“幽门螺杆菌”和“胃癌”或“肠道微生物组”和“炎症性肠病”或“口腔微生物组”和“系统性疾病”。
牙周炎引起的口腔微生物群的生态失调变化直接和间接地与 IBS、神经退行性疾病、肌肉关节疾病、呼吸道感染和胃肠道癌症等系统性疾病相关；这凸显了保持口腔卫生以预防口腔疾病和系统性疾病的重要性。更好地理解口腔健康和系统性疾病之间的联系将整合口腔健康管理，提供新的预防、诊断和治疗机会，以改善整体患者结局。
