Huang Shi, Lu Yaxin, Fang Wanzhen, Huang Yanjiao, Li Qiang, Xu Zhiliang
School of Clinical Medicine, Wannan Medical College, 241002, Wuhu, Anhui, China.
School of Pharmaceutical Sciences, Wannan Medical College, 241002, Wuhu, Anhui, China.
Open Life Sci. 2025 Feb 25;20(1):20221051. doi: 10.1515/biol-2022-1051. eCollection 2025.
Neuroinflammation represents a critical pathway in the brain for the clearance of foreign bodies and the maintenance of homeostasis. When the neuroinflammatory process is dysregulate, such as the over-activation of microglia, which results in the excessive accumulation of free oxygen and inflammatory factors in the brain, among other factors, it can lead to an imbalance in homeostasis and the development of various diseases. Recent research has indicated that the development of numerous neurodegenerative diseases is closely associated with neuroinflammation. The pathogenesis of neuroinflammation in the brain is intricate, involving alterations in numerous genes and proteins, as well as the activation and inhibition of signaling pathways. Furthermore, excessive inflammation can result in neuronal cell apoptosis, which can further exacerbate the extent of the disease. This article presents a summary of recent studies on the relationship between neuronal apoptosis caused by excessive neuroinflammation and neurodegenerative diseases. The aim is to identify the link between the two and to provide new ideas and targets for exploring the pathogenesis, as well as the prevention and treatment of neurodegenerative diseases.
神经炎症是大脑中清除异物和维持体内平衡的关键途径。当神经炎症过程失调时，例如小胶质细胞过度激活，导致大脑中游离氧和炎症因子过度积累等，会导致体内平衡失衡并引发各种疾病。最近的研究表明，许多神经退行性疾病的发生与神经炎症密切相关。大脑中神经炎症的发病机制错综复杂，涉及众多基因和蛋白质的改变，以及信号通路的激活和抑制。此外，过度炎症可导致神经元细胞凋亡，这会进一步加剧疾病的程度。本文总结了近期关于过度神经炎症引起的神经元凋亡与神经退行性疾病之间关系的研究。目的是确定两者之间的联系，并为探索神经退行性疾病的发病机制以及预防和治疗提供新的思路和靶点。
