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2
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Int J Environ Res Public Health. 2023 Feb 27;20(5):4206. doi: 10.3390/ijerph20054206.
3
Cannabidiol exposures in the United States, National Poison Data System, July 2014-June 2021.美国 2014 年 7 月至 2021 年 6 月期间国家毒物数据系统的大麻二酚暴露情况。
Clin Toxicol (Phila). 2023 Feb;61(2):123-130. doi: 10.1080/15563650.2022.2156881. Epub 2022 Dec 20.
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Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials.医学大麻或大麻素治疗慢性非癌症和癌症相关疼痛:随机临床试验的系统评价和荟萃分析。
BMJ. 2021 Sep 8;374:n1034. doi: 10.1136/bmj.n1034.
5
Associations of Suicidality Trends With Cannabis Use as a Function of Sex and Depression Status.自杀趋势与大麻使用的关联,按性别和抑郁状态的不同而有所差异。
JAMA Netw Open. 2021 Jun 1;4(6):e2113025. doi: 10.1001/jamanetworkopen.2021.13025.
6
Unwitting adult marijuana poisoning: a case series.无意的成人大麻中毒:病例系列。
Clin Toxicol (Phila). 2021 Oct;59(10):913-917. doi: 10.1080/15563650.2021.1891241. Epub 2021 Mar 10.
7
Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review.大麻二酚与药物、非法物质和酒精的相互作用:全面综述。
J Gen Intern Med. 2021 Jul;36(7):2074-2084. doi: 10.1007/s11606-020-06504-8. Epub 2021 Jan 29.
8
Medical Cannabis for Older Patients-Treatment Protocol and Initial Results.老年患者的医用大麻——治疗方案与初步结果
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9
Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.大麻二酚对各种新型抗癫痫药物在电休克和 6Hz 诱导的小鼠惊厥中的急性作用:药效学和药代动力学研究。
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10
Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives.大麻对大脑结构、功能和认知的影响:考虑大麻及其衍生物的医疗用途。
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探索概况:老年人使用大麻的情况剖析

Exploring The Contours: Navigating Cannabis Use Among Older Adults.

作者信息

Shin Yoo Mee, Moussa Mohamad, Akwe Joyce

机构信息

Division of Hospital Medicine Emory University School of Medicine.

Atlanta VAHCS/ VISN 7 Clinical Resource Hub.

出版信息

J Brown Hosp Med. 2024 Jul 1;3(3):120951. doi: 10.56305/001c.120951. eCollection 2024.

DOI:10.56305/001c.120951
PMID:40026396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11864428/
Abstract

Cannabis has been employed medicinally throughout history, with recent renewed interest for use due to media awareness and medical marijuana legislation. The geriatric population, identified as those 65 years of age and older, is increasingly using cannabis-derived products, has a higher likelihood of having multiple comorbidities, and is subject to polypharmacy. These individuals are at increased risk of psychiatric and other medical adverse events due to their decreased physical and cognitive reserve and changes in their physicality. Recreational use of cannabis in this population has not been well studied, but medical marijuana use has been investigated more frequently. Increased nonmedical use increases the risk of adverse health consequences. Heavy regular use can lead to cannabis use disorder (CUD), which is formerly known as cannabis abuse and dependence, and may also lead to impaired social functioning and psychiatric comorbidity. The pattern of patients admitted to hospitals has dramatically changed recently, with an increased number of elderly patients being frequently admitted. As such, due to the ease of accessing CBD, this vulnerable cohort is seen more frequently in the hospital, and we need to be more vigilant and inquire about cannabis use as we do, asking about routine medications and over-the-counter supplements. In the U.S., marijuana laws have been changing rapidly, and Americans increasingly favor legalizing cannabis for medical and recreational uses. Policymakers should ensure that training on cannabis screening and interventions for CUD are provided to clinicians to equip them better to monitor and treat patients with cannabis-related problems.

摘要

纵观历史,大麻一直被用于医学领域,由于媒体的关注和医用大麻立法,近期人们对其使用的兴趣再度燃起。老年人群体指65岁及以上的人群,他们越来越多地使用大麻衍生产品,患多种合并症的可能性更高,且常服用多种药物。由于身体和认知储备下降以及身体机能变化,这些人出现精神和其他医疗不良事件的风险增加。该人群中大麻的娱乐性使用尚未得到充分研究,但医用大麻的使用已得到更频繁的调查。非医疗用途的增加会增加不良健康后果的风险。长期大量使用大麻会导致大麻使用障碍(CUD),该障碍以前被称为大麻滥用和依赖,还可能导致社会功能受损和精神共病。最近,入院患者的模式发生了巨大变化,老年患者入院的数量不断增加。因此,由于获取大麻二酚(CBD)较为容易,在医院中更容易见到这个脆弱的群体,我们需要更加警惕,像询问常规药物和非处方补充剂一样询问大麻的使用情况。在美国,大麻法律一直在迅速变化,美国人越来越倾向于将大麻用于医疗和娱乐用途合法化。政策制定者应确保为临床医生提供有关大麻筛查和大麻使用障碍干预措施的培训,以使他们能更好地监测和治疗有大麻相关问题的患者。