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营养干预改善帕金森病患者生活质量及非运动症状:一项病例研究

Quality of Life and non-motor symptoms Improvement in Parkinson's Disease through Nutritional Intervention: a Case Study.

作者信息

Zanini Milko, Simonini Marina, Giusti Antonella, Aleo Giuseppe, Ripamonti Stefania, Delbene Lara, Musio Maria Emma, Sasso Loredana, Catania Gianluca, Bagnasco Annamaria

机构信息

Department of Health Sciences, University of Genoa, Italy.

UOC Recovery and Functional Rehabilitation, La Colletta Hospital ASL 3 Genovese, Genoa, Italy.

出版信息

J Prev Med Hyg. 2025 Jan 31;65(4):E555-E562. doi: 10.15167/2421-4248/jpmh2024.65.4.3322. eCollection 2024 Dec.

Abstract

Non-motor symptomatology in Parkinson's disease (PD) is related to patients' quality of life (QoL). The Non-Motor Symptoms Scale (NNMS) assesses QoL by investigating numerous domains including nutritional status, which is represented by domain 6. Patients with PD commonly suffer from dysphagia, and consequently malnutrition, leading to sarcopenia and increasing motor deficits in relation to loss of muscle mass and energy deficit. The impact of dysphagia on PD patients' health status, makes it necessary to study the effectiveness of specific nutritional programs in addressing feeding needs, with the goal to improve clinical outcomes and the patient's perception of their QoL. The 'Weancare' Program was trialed on an 84-year-old PD patient suffering from dysphagia and the Tower of Pisa Syndrome. The first assessment of the patient showed an early overall deteriorating condition, particularly under a nutritional point of view. The patient was assessed before and after the intervention considering serological tests, and the QoL through the New Non-Motor Symptoms Scale (NNMS). We found a beneficial impact of the 'Weancare' program on the patient significantly improving the non-motor symptomatology and QoL and the investigated outcomes, enhancing a better subjective experience of mealtime lived by the patient.

摘要

帕金森病(PD)的非运动症状与患者的生活质量(QoL)相关。非运动症状量表(NNMS)通过调查包括营养状况(由第6个领域代表)在内的众多领域来评估生活质量。PD患者通常会出现吞咽困难,进而导致营养不良,导致肌肉减少症,并因肌肉量减少和能量不足而增加运动功能障碍。吞咽困难对PD患者健康状况的影响,使得有必要研究特定营养方案在满足喂养需求方面的有效性,目标是改善临床结果以及患者对其生活质量的认知。“Weancare”方案在一名患有吞咽困难和比萨斜塔综合征的84岁PD患者身上进行了试验。对该患者的首次评估显示其整体状况早期恶化,尤其是在营养方面。在干预前后对患者进行了血清学检查评估,并通过新的非运动症状量表(NNMS)评估了生活质量。我们发现“Weancare”方案对患者有有益影响,显著改善了非运动症状和生活质量以及所研究的结果,增强了患者用餐时更好的主观体验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe88/11870126/3cb61e1897ff/jpmh-2024-04-e555-g001.jpg

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