Han Xiaorong, Liu Jinxing, Gu Yingzhen, Li Yifan, Zhang Wei, Lv Naqiang, Dang Aimin
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, China.
Rev Cardiovasc Med. 2025 Feb 19;26(2):26437. doi: 10.31083/RCM26437. eCollection 2025 Feb.
Statin therapy is associated with an increased risk of new-onset diabetes (NOD), possibly due to a reduction in coenzyme Q10 (CoQ10) levels as a result of statin use. This study aimed to investigate the relationship between exogenous CoQ10 supplementation and the development of NOD.
This study included 4394 participants from the National Health and Nutrition Examination Survey (NHANES). Baseline characteristics were compared between those with and without NOD and between those with and without CoQ10. Univariate logistic regression was performed to identify factors associated with NOD. Two models were used for confounding factors, including demographics and various covariates. Multifactor logistic regression further assessed the association between CoQ10 supplementation and NOD. Additionally, restricted cubic spline (RCS) analysis was conducted to evaluate the potential nonlinear relationship between daily CoQ10 dose and NOD.
Univariate logistic regression showed an association between CoQ10 supplementation and a reduced risk of NOD (odds ratio [OR] = 0.323, 95% confidence interval [CI] 0.157-0.668, = 0.003), which remained significant after adjustments in model 1 (OR = 0.344, 95% CI 0.160-0.737, = 0.006) and model 2 (OR = 0.232, 95% CI 0.057-0.942, = 0.041). There was no evidence of a linear association between daily CoQ10 dose and NOD in logistic regression analysis (OR = 0.999, 95% CI 0.994-1.004, = 0.720), and no evidence of a nonlinear correlation in the RCS analysis ( > 0.05).
CoQ10 supplementation in individuals taking statins was associated with a reduced risk of NOD, and this association was independent of the CoQ10 dose.
他汀类药物治疗与新发糖尿病（NOD）风险增加相关，这可能是由于使用他汀类药物导致辅酶Q10（CoQ10）水平降低所致。本研究旨在探讨外源性补充CoQ10与NOD发生之间的关系。
本研究纳入了来自美国国家健康与营养检查调查（NHANES）的4394名参与者。比较了有和没有NOD的参与者以及有和没有CoQ10的参与者的基线特征。进行单因素逻辑回归以确定与NOD相关的因素。使用两个模型来处理混杂因素，包括人口统计学和各种协变量。多因素逻辑回归进一步评估了补充CoQ10与NOD之间的关联。此外，进行了受限立方样条（RCS）分析以评估每日CoQ10剂量与NOD之间的潜在非线性关系。
单因素逻辑回归显示补充CoQ10与NOD风险降低相关（比值比[OR]=0.323，95%置信区间[CI]0.157 - 0.668，P = 0.003），在模型1调整后（OR = 0.344，95%CI 0.160 - 0.737，P = 0.006）和模型2调整后（OR = 0.232，95%CI 0.057 - 0.942，P = 0.041）仍然显著。逻辑回归分析中没有证据表明每日CoQ10剂量与NOD之间存在线性关联（OR = 0.999，95%CI 0.994 - 1.004，P = 0.720），RCS分析中也没有证据表明存在非线性相关性（P>0.05）。
服用他汀类药物的个体补充CoQ10与NOD风险降低相关，且这种关联与CoQ10剂量无关。
