Shen Hao, Xu Li, Lu Jingfen, Hao Tianbo, Ma Chunfang, Yang Honglin, Lu Zhaoyang, Gu Yongchun, Zhu Tonghua, Shen Guorong
Department of Clinical Laboratory Medicine, The First People's Hospital of Wujiang, Affliated Wujiang Hospital of Nantong University, Suzhou, China.
Department of General Surgery, The First People's Hospital of Wujiang, Affliated Wujiang Hospital of Nantong University, Suzhou, China.
Lipids Health Dis. 2015 Oct 29;14:137. doi: 10.1186/s12944-015-0143-x.
Small dense low-density lipoprotein cholesterol (sdLDL-C) concentration was useful in the assessment of the presence of cardiovascular diseases (CVD) and its severity. We examined whether SdLDL-C is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and traditional CVD risk factors in Chinese healthy subjects.
We measured CA-IMT, blood pressure (BP), sdLDL-C, glucose metabolism and lipid in 183 native Chinese healthy subjects. CA-IMT was assessed by ultrasonography, and sdLDL-C concentrations were measured by a homogenous assay. Pearson's correlation coefficient analyses and Multiple regression analyses were used to examine the relationships between CA-IMT values and other clinical variables.
The sdLDL-C level was significantly higher in males than in females (p <0.05) and there was an age effect on sdLDL-C (p <0.05). When the effects of age, gender and other traditional CVD risk factors were adjusted using multiple regression analysis. CA-IMT remained significantly associated with sdLDL-C(β = 0.437, p <0.001).
There are gender and age differences in sdLDL-C levels among a healthy Chinese population. Moreover, we found adjusted traditional CVD risk factors such as higher age, male sex, and other traditional CVD risk factors, the association between CA-IMT and SdLDL-C remained significant. sdLDL-C is may be a useful predictor in the assessment of CA-IMT in Chinese population.
小而密低密度脂蛋白胆固醇（sdLDL-C）浓度有助于评估心血管疾病（CVD）的存在及其严重程度。我们研究了在中国健康受试者中，与低密度脂蛋白胆固醇（LDL-C）和传统CVD危险因素相比，sdLDL-C是否与颈动脉内膜中层厚度（CA-IMT，动脉粥样硬化的替代指标）的相关性更强。
我们测量了183名中国本土健康受试者的CA-IMT、血压（BP）、sdLDL-C、糖代谢和血脂。通过超声检查评估CA-IMT，采用均相测定法测量sdLDL-C浓度。采用Pearson相关系数分析和多元回归分析来研究CA-IMT值与其他临床变量之间的关系。
男性的sdLDL-C水平显著高于女性（p <0.05），且sdLDL-C存在年龄效应（p <0.05）。当使用多元回归分析调整年龄、性别和其他传统CVD危险因素的影响后，CA-IMT仍与sdLDL-C显著相关（β = 0.437，p <0.001）。
中国健康人群中sdLDL-C水平存在性别和年龄差异。此外，我们发现调整年龄、性别和其他传统CVD危险因素后，CA-IMT与sdLDL-C之间的关联仍然显著。sdLDL-C可能是评估中国人群CA-IMT的有用预测指标。
