Fontana Liliana Berté, Henn Guilherme Schwingel, Dos Santos Carolina Horst, Specht Luana, Schmitz Caroline, Volken de Souza Claucia Fernanda, Lehn Daniel Neutzling
Graduate Program in Biotechnology, Universidade do Vale do Taquari - Univates, Lajeado 95900-000, Rio Grande do Sul, Brazil.
American Nutrients do Brasil Indústria e Comércio Ltda, Teutônia 95890-000, Rio Grande do Sul, Brazil.
ACS Omega. 2025 Feb 13;10(7):6294-6305. doi: 10.1021/acsomega.4c08080. eCollection 2025 Feb 25.
The search for alternatives to certain antibiotics in animal nutrition has propelled the study of encapsulated essential oils and organic acids considering their potential to generate beneficial effects in animal organisms. The objective of this study was to compile and discuss scientific findings published between 2013 and July 2024 from two databases related to the usage of encapsulated essential oils and organic acids in the supplementation of poultry and swine feeds. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) methodology, covering the PubMed and Web of Science databases, which initially yielded 115 selected articles. After applying the inclusion and exclusion criteria, 21 relevant articles were selected for comprehensive analysis. The studies demonstrate that the encapsulation of essential oils and organic acids is an alternative to reduce the utilization of conventional antibiotics, as encapsulation has the potential to maintain the properties of these compounds while ensuring greater stability and controlled release within the animal organism. The selection of appropriate encapsulation technologies, encapsulating agents, and zootechnical additives is crucial to maximizing the effectiveness of these compounds in animal nutrition. Despite the identification of gaps in the analyzed studies regarding specific details of the techniques used and regulatory considerations, encapsulated essential oils and organic acids show potential to reduce the need for antibiotics in animal production along with other added benefits. This Review provides a comprehensive overview of the subject, aiming to guide and contribute to future research efforts.
在动物营养领域寻找某些抗生素的替代品，促使人们对包封精油和有机酸进行研究，因为它们有可能在动物机体中产生有益效果。本研究的目的是汇编并讨论2013年至2024年7月期间从两个数据库发表的关于在禽畜饲料补充中使用包封精油和有机酸的科学研究结果。按照系统评价和荟萃分析的首选报告项目（PRISMA）方法进行了系统评价，涵盖了PubMed和科学网数据库，最初筛选出115篇文章。在应用纳入和排除标准后，选择了21篇相关文章进行全面分析。研究表明，精油和有机酸的包封是减少传统抗生素使用的一种替代方法，因为包封有可能保持这些化合物的特性，同时确保在动物机体内具有更高的稳定性和控释性。选择合适的包封技术、包封剂和畜牧添加剂对于在动物营养中最大限度地提高这些化合物的有效性至关重要。尽管在所分析的研究中发现了关于所用技术的具体细节和监管考虑方面的差距，但包封精油和有机酸显示出减少动物生产中抗生素需求的潜力以及其他附加益处。本综述对该主题进行了全面概述，旨在指导并推动未来的研究工作。
