Alsharif Bashaer, Biasiotti Matilde, Bader Ammar, Kukula-Koch Wirginia, Davey Gavin P, Boylan Fabio
School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Nat Prod Res. 2025 Mar 3:1-6. doi: 10.1080/14786419.2025.2472272.
Plants in the genus Pistacia represent valuable natural resources for neuroprotective research based on ethnomedicinal knowledge. While other Pistacia species have been extensively studied, () has received limited attention. This study aimed to characterise the phenolic compounds in extract using HPLC-DAD-MS/MS and evaluate its neuroprotective potential by assessing its ability to inhibit important central nervous system (CNS) enzymes-acetylcholinesterase (AChE) and monoamine oxidases (MAO-A and MAO-B). displayed a rich profile of phenolic acids and unique glucuronidated flavonoids, contributing to its potent antioxidant activity (IC50 23.37 ± 0.63 µg/mL). The extract exhibited a stronger inhibitory effect on MAO-B than MAO-A and inhibited AChE (IC50 0.22 ± 0.01 mg/mL). These findings suggest that has significant neuroprotective potential, warranting further investigation as a source of functional food and nutraceutical ingredients for managing neurodegenerative diseases.
黄连木属植物是基于民族医学知识进行神经保护研究的宝贵自然资源。虽然其他黄连木属物种已得到广泛研究，但（此处缺失物种名）受到的关注有限。本研究旨在利用高效液相色谱-二极管阵列-串联质谱法（HPLC-DAD-MS/MS）对（此处缺失物种名）提取物中的酚类化合物进行表征，并通过评估其抑制重要中枢神经系统（CNS）酶——乙酰胆碱酯酶（AChE）和单胺氧化酶（MAO-A和MAO-B）的能力来评估其神经保护潜力。（此处缺失物种名）展现出丰富的酚酸谱和独特的葡萄糖醛酸化黄酮类化合物，这使其具有强大的抗氧化活性（半数抑制浓度[IC50]为23.37±0.63μg/mL）。该提取物对MAO-B的抑制作用强于MAO-A，并能抑制AChE（IC50为0.22±0.01mg/mL）。这些发现表明，（此处缺失物种名）具有显著的神经保护潜力，作为用于管理神经退行性疾病的功能性食品和营养成分来源值得进一步研究。
