Acetylcholinesterase and monoamine oxidase inhibitory activities of Becc. ex Martelli extract.

Plants in the genus Pistacia represent valuable natural resources for neuroprotective research based on ethnomedicinal knowledge. While other Pistacia species have been extensively studied, () has received limited attention. This study aimed to characterise the phenolic compounds in extract using HPLC-DAD-MS/MS and evaluate its neuroprotective potential by assessing its ability to inhibit important central nervous system (CNS) enzymes-acetylcholinesterase (AChE) and monoamine oxidases (MAO-A and MAO-B). displayed a rich profile of phenolic acids and unique glucuronidated flavonoids, contributing to its potent antioxidant activity (IC50 23.37 ± 0.63 µg/mL). The extract exhibited a stronger inhibitory effect on MAO-B than MAO-A and inhibited AChE (IC50 0.22 ± 0.01 mg/mL). These findings suggest that has significant neuroprotective potential, warranting further investigation as a source of functional food and nutraceutical ingredients for managing neurodegenerative diseases.