Hunt Bijou, Pham Alice, Glick Nancy, Sam Sharon, Ni Keyang, Meyers Kathrine, Nguyen Nadia
Sinai Infectious Disease Center, Sinai Chicago, Chicago, IL, USA.
Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
AIDS Behav. 2025 May;29(5):1704-1712. doi: 10.1007/s10461-024-04610-w. Epub 2025 Mar 3.
Long-acting injectable antiretroviral treatment (LAI ART) has the potential to transform HIV care and reduce HIV-related health inequities in achieving and maintaining viral suppression. However, without a plan for equitable roll-out of LAI ART, new pharmacological innovations in HIV treatment and prevention risk further deepening health disparities. This study delineates a process for providing universal LAI ART education to people with HIV (PWH) at an urban outpatient infectious disease clinic and documents the outcomes of these efforts. We compared the number and proportion of patients with HIV educated about injectable cabotegravir-rilpivirine (iCAB/RPV) and, among those educated, the number and proportion of patients interested in learning more about iCAB/RPV under a selective education model compared to a universal education model, disaggregated by race/ethnicity, sex, and age. We used a Chi-sq test to estimate p-values for the difference in proportions. The universal compared to selective education approach resulted in a larger proportion of clients educated and a greater proportion of people educated reporting interest in LAI ART. Slight differences observed between those never versus ever educated in the selective education were absent after the adoption of a universal education approach. Reasons for disinterest -- including fear of injections, not interested in more frequent clinic visits, and content with oral ART regimen -- did not differ across educational approaches. Our programmatic data offers preliminary evidence that a universal education approach can support and enhance equitable roll-out of LAI ART. Most patients with HIV are interested in learning more about LAI ART.
长效注射用抗逆转录病毒治疗（LAI ART）有潜力改变艾滋病护理模式，并在实现和维持病毒抑制方面减少与艾滋病相关的健康不平等现象。然而，如果没有公平推出LAI ART的计划，艾滋病治疗和预防方面的新药理学创新可能会进一步加深健康差距。本研究描述了在一家城市门诊传染病诊所为艾滋病患者（PWH）提供普及LAI ART教育的过程，并记录了这些努力的成果。我们比较了接受注射用卡博特韦-利匹韦林（iCAB/RPV）教育的艾滋病患者的数量和比例，以及在选择性教育模式与普及教育模式下，按种族/民族、性别和年龄分类的接受教育的患者中对进一步了解iCAB/RPV感兴趣的患者数量和比例。我们使用卡方检验来估计比例差异的p值。与选择性教育方法相比，普及教育方法使接受教育的客户比例更高，且接受教育的人中表示对LAI ART感兴趣的比例更大。在采用普及教育方法后，选择性教育中从未接受过教育与曾经接受过教育的人之间观察到的细微差异消失了。不感兴趣的原因——包括害怕打针、对更频繁的门诊就诊不感兴趣以及对口服抗逆转录病毒治疗方案满意——在不同教育方法中并无差异。我们的项目数据提供了初步证据，表明普及教育方法可以支持并加强LAI ART的公平推出。大多数艾滋病患者有兴趣进一步了解LAI ART。
