Wiklund B, Hallberg D
Acta Chir Scand. 1985;151(2):159-62.
Intussusception valves were created in the small intestine of jejunoileal bypass-operated dogs and patients with the intention to prevent reflux of chyme into the excluded intestinal loop and thereby increase weight loss. In the dogs the valves were shown to withstand a pressure of at least 100 cm of water. All patients with end-to-side bypass were at X-ray examination found to have sufficient valves whereas only four of fourteen with end-to-end bypass, where the defunctionalized loop was implanted into the cecum, had tight valves. During five years of observation no significant difference in weight loss was seen between the patients with valves and control groups without valves. It is concluded that reflux of chyme only plays a minor role for weight loss after jejunoileal bypass for obesity.
肠套叠瓣膜是在接受空肠回肠分流手术的狗和患者的小肠中制造的，目的是防止食糜反流到被排除的肠袢中，从而增加体重减轻。在狗身上，这些瓣膜被证明能够承受至少100厘米水柱的压力。在X线检查中发现，所有行端侧分流的患者都有足够的瓣膜，而在14例行端端分流（即将失功能的肠袢植入盲肠）的患者中，只有4例瓣膜紧密。在五年的观察期内，有瓣膜的患者与无瓣膜的对照组在体重减轻方面没有显著差异。得出的结论是，对于肥胖患者的空肠回肠分流术后体重减轻，食糜反流只起次要作用。
