超越与Rap1的相互作用：剖析Rif1的作用

Beyond interacting with Rap1: Dissecting the roles of Rif1.

作者信息

Wei Jiyu, Sun Hao, Huang Zhihong, Yang Liqian, Wu Jiaxing, Zhang Jiaqi, Liu Minghui, Li Meiting, Luo Jianyuan, Wang Haiying

机构信息

Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

出版信息

Int J Biol Macromol. 2025 May;306(Pt 3):141560. doi: 10.1016/j.ijbiomac.2025.141560. Epub 2025 Mar 1.

DOI:10.1016/j.ijbiomac.2025.141560

PMID:40032092

Abstract

Rap1 interacting factor 1 (Rif1), an evolutionarily conserved protein discovered in budding yeast, is crucial for controlling telomere length when it interacts with Rap1. Recent research, however, has shown that Rif1 not only controls telomere length and homeostasis, but also plays a role in transcriptional silencing, DNA replication timing, DNA replication fork protection, DNA damage repair and chromatin architecture. In this review, we summarize the current understanding of Rif1 in structure, function, and regulation, especially its relevance to cancer hallmarks. Also, we discuss its role as a regulator in the pathogenesis of disease.

摘要

Rap1相互作用因子1（Rif1）是在芽殖酵母中发现的一种进化保守蛋白，当它与Rap1相互作用时，对控制端粒长度至关重要。然而，最近的研究表明，Rif1不仅控制端粒长度和稳态，还在转录沉默、DNA复制时间、DNA复制叉保护、DNA损伤修复和染色质结构中发挥作用。在这篇综述中，我们总结了目前对Rif1在结构、功能和调控方面的理解，特别是它与癌症特征的相关性。此外，我们还讨论了它作为疾病发病机制中的调节因子的作用。