Roghanizadeh Leyla, Atarbashi-Moghadam Saede, Masaebi Fatemeh, Baghban Alireza Akbarzadeh
Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113, Iran.
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sci Rep. 2025 Mar 3;15(1):7389. doi: 10.1038/s41598-025-92090-w.
The global burden of disease (GBD) provides valid and reliable assessments of the burden of various diseases. The present study aimed to evaluate the trends of incidence, mortality, and morbidity of lips and oral cavity cancers (LOCC) in Iran from 1990 to 2019 according to GBD 2019 data. Indicators including prevalence, incidence, death, years of life lost (YLL), years lived with disability (YLD), disability adjusted life years (DALY), and mortality-to-incidence ratio (MIR) for two genders and three age groups including 15-49 years, 50-69 years, and 70 + years in Iran were extracted from GBD 2019/calculated. The annual percentage changes of different indicators were analyzed. A joinpoint regression analysis was used to examine the pattern of changes. LOCC incidence in Iran has increased during the studied period, in both genders and all age groups. The average annual percent change (AAPC) of incidence increase was much higher in women (1.36) than in men (0.007), while the highest growth was observed in middle-aged women from 2010 to 2015 (6.9). The general trend (AAPC (Confidence interval (CI)) of YLL in total patients (-0.20 (-0.23, -0.17)), and DALY in total patients (-0.17 (-0.21, -0.14)) had a significant decrease. However, YLL in women (0.48 (0.44, 0.50)) and DALY in women (0.51 (0.48, 0.54)) significantly increased. Moreover, MIR has been declining during the studied period except for the time range of 2002 to 2010, in each of the two sexes (-0.46 in men and - 0.64 in women) and both together (-0.53). A declining trend of YLL/DALY/MIR, and an improvement in screening/diagnosis/treatment/patient care of LOCC in Iran has happened that still needs to be improved. Due to the increase in incidence/mortality/morbidity of LOCC in Iranian women, risk factors exposure and disease screening should be followed seriously.
全球疾病负担（GBD）对各种疾病的负担提供了有效且可靠的评估。本研究旨在根据GBD 2019数据评估1990年至2019年伊朗唇癌和口腔癌（LOCC）的发病率、死亡率和患病率趋势。从GBD 2019中提取/计算了伊朗两个性别以及三个年龄组（包括15 - 49岁、50 - 69岁和70岁及以上）的患病率、发病率、死亡、生命损失年数（YLL）、带病生存年数（YLD）、伤残调整生命年（DALY）以及死亡率与发病率之比（MIR）等指标。分析了不同指标的年度百分比变化。采用连接点回归分析来检验变化模式。在研究期间，伊朗的LOCC发病率在两个性别和所有年龄组中均有所上升。女性发病率增加的平均年度百分比变化（AAPC）（1.36）远高于男性（0.007），而在2010年至2015年期间中年女性的增长最为显著（6.9）。总体患者的YLL（-0.20（-0.23，-0.17））和DALY（-0.17（-0.21，-0.14））的总体趋势有显著下降。然而，女性的YLL（0.48（0.44，0.50））和女性的DALY（0.51（0.48，0.54））显著增加。此外，在研究期间，除了2002年至2010年这个时间段外，两个性别的MIR均呈下降趋势（男性为-0.46，女性为-0.64），两者综合起来为-0.53。伊朗已经出现了YLL/DALY/MIR的下降趋势以及LOCC筛查/诊断/治疗/患者护理方面的改善，但仍需改进。由于伊朗女性中LOCC的发病率/死亡率/患病率增加,应认真关注危险因素暴露和疾病筛查。
