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茶消费与肝脂肪变性和肝纤维化的关系:来自纵向RaNCD队列的研究结果

Relationship of tea consumption with hepatic steatosis and fibrosis: findings from a longitudinal RaNCD cohort.

作者信息

Qaisar Shaimaa A, Moludi Jalal, Shahnazi Narges, Soleimani Davood, Pasdar Yahya

机构信息

Garmin University Research Center, kalar. Sulymaniyah, Iraq.

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

BMC Nutr. 2025 Mar 3;11(1):47. doi: 10.1186/s40795-025-01032-2.

Abstract

BACKGROUND

Tea, known for its high content of antioxidants and anti-inflammatory compounds such as catechins, is believed to support liver health. This study aimed to explore the relationship between tea consumption and hepatic steatosis and fibrosis.

METHODS

This longitudinal study involved 2,537 participants from the Ravanser Non-Communicable Disease (RaNCD) cohort, conducted from 2015 to 2023. Dietary intake was evaluated using a 118-item food frequency questionnaire (FFQ). The Fibrosis-4 (FIB-4) index and the Hepatic Steatosis Index (HSI) were utilized as predictive indicators for hepatic fibrosis and steatosis, respectively.

RESULTS

After adjusting for potential confounding factors, our findings indicated that tea consumption was not significantly associated with an increased risk of worsening hepatic steatosis or fibrosis (P-value > 0.05). However, participants who consumed more than 2.88 cups of tea per day had a 27% lower likelihood of experiencing improvement in hepatic steatosis compared to those who consumed less than 1.92 cups per day (Relative Risk: 0.73; 95% CI: 0.53-0.99; P-value: 0.046).

CONCLUSION

Our study suggests that higher tea consumption is not significantly linked to an elevated risk of worsening hepatic steatosis or fibrosis. However, it is noteworthy that individuals who consumed more tea were less likely to see improvements in hepatic steatosis. This finding highlights the need for further research to better understand the potential effects of tea on liver health.

摘要

背景

茶以其高含量的抗氧化剂和抗炎化合物(如儿茶素)而闻名,被认为有助于肝脏健康。本研究旨在探讨茶的摄入量与肝脂肪变性和肝纤维化之间的关系。

方法

这项纵向研究涉及2015年至2023年期间拉万瑟尔非传染性疾病(RaNCD)队列中的2537名参与者。使用一份包含118个条目的食物频率问卷(FFQ)评估饮食摄入量。纤维化-4(FIB-4)指数和肝脂肪变性指数(HSI)分别用作肝纤维化和肝脂肪变性的预测指标。

结果

在对潜在混杂因素进行调整后,我们的研究结果表明,茶的摄入量与肝脂肪变性或肝纤维化恶化风险的增加没有显著关联(P值>0.05)。然而,与每天饮用少于1.92杯茶的参与者相比,每天饮用超过2.88杯茶的参与者肝脂肪变性改善的可能性低27%(相对风险:0.73;95%置信区间:0.53-0.99;P值:0.046)。

结论

我们的研究表明,较高的茶摄入量与肝脂肪变性或肝纤维化恶化风险的升高没有显著关联。然而,值得注意的是,饮用较多茶的个体肝脂肪变性改善的可能性较小。这一发现凸显了需要进一步研究以更好地了解茶对肝脏健康的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d327/11877829/bd746740f490/40795_2025_1032_Fig1_HTML.jpg

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