Department of Endocrinology, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan City, Shandong Province, China.
Department of Internal Medicine, Jinan Central Hospital, Jinan, Shandong Province, China.
Phytother Res. 2020 Oct;34(10):2459-2470. doi: 10.1002/ptr.6697. Epub 2020 May 5.
The effects of green tea (GT) in obese subjects have been evaluated in different studies, but no consensus has been obtained due to the heterogeneity of the results. The dosage, the type of extract, and the duration of the intervention are the main contributors to the heterogeneity of the results. Therefore, the present systematic review and meta-analysis aimed to evaluate the efficacy and dose-response relationship of GT. Several databases were searched from inception to September 2019 to identify clinical trials that examined the influence of GT supplements on obesity indices in humans. Combined results using the random-effects model indicated that body weight (WMD: -1.78 kg, 95% CI: -2.80, -0.75, p = .001) and body mass index (BMI) (WMD: -0.65 kg/m , 95% CI: -1.04, -0.25, p = .001) did change significantly following GT administration. The reduction in waist circumference (WC) after GT consumption was significant in subjects in trials employing GT ≥800 mg/day (WMD: -2.06 cm) and with a treatment duration <12 weeks (WMD: -2.39 cm). Following the dose-response evaluation, GT intake did alter body weight, with a more important reduction when the GT dosage was <500 mg/day and the treatment duration was of 12 weeks. The results of present meta-analysis study support the use of GT for the improvement of obesity indices. Thus, we suggest that the use of GT can be combined with a balanced and healthy diet and regular physical exercise in the management of obese patients.
绿茶（GT）对肥胖人群的影响已在不同的研究中进行了评估，但由于结果的异质性，尚未得出共识。剂量、提取物类型和干预持续时间是导致结果异质性的主要因素。因此，本系统评价和荟萃分析旨在评估 GT 的疗效和剂量反应关系。从开始到 2019 年 9 月，我们检索了多个数据库，以确定检查 GT 补充剂对人体肥胖指数影响的临床试验。使用随机效应模型对合并结果进行分析表明，体重（WMD：-1.78kg，95%CI：-2.80，-0.75，p=0.001）和体重指数（BMI）（WMD：-0.65kg/m，95%CI：-1.04，-0.25，p=0.001）在服用 GT 后确实发生了显著变化。在采用 GT≥800mg/天（WMD：-2.06cm）和治疗持续时间<12 周（WMD：-2.39cm）的试验中，GT 消耗后腰围（WC）的减少具有统计学意义。在进行剂量反应评估后，GT 摄入量确实改变了体重，当 GT 剂量<500mg/天且治疗持续时间为 12 周时，体重的减轻更为明显。本荟萃分析研究的结果支持使用 GT 来改善肥胖指数。因此，我们建议在肥胖患者的管理中，可以将 GT 的使用与均衡健康的饮食和定期体育锻炼相结合。
