Bouron M, Beccaria K, Debaisieux J, Moro M R, Blanchet Corinne
Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Maison de Solenn- Maison des Adolescents, Paris, France.
Department of Pediatric Neurosurgery, Assistance Publique-Hôpitaux de Paris, Necker-Enfants Malades Hospital, Paris, France.
J Eat Disord. 2025 Mar 3;13(1):41. doi: 10.1186/s40337-025-01195-0.
Avoidant/Restrictive Food Intake Disorder (ARFID) is a recently recognized eating disorder category in the DSM-5 and ICD-11classifications. Recent functional neuroimaging studies have suggested alterations in the cerebellar intrinsic connectivity networks in patients suffering from eating disorders. Associations between eating disorders and central nervous system tumors have been documented, but to date no studies have linked eating disorders to cerebellar lesions. This case report presents a 13-year-old boy with ARFID symptoms and a cerebellar tumor, exploring the potential connection between the two.
A 13-year-old adolescent with a history of dental agenesis, escalating food restriction, severe abdominal pain, impaired weight gain and statural growth was initially diagnosed with ARFID. A brain magnetic resonance imaging revealed a large and threatening cerebellar tumor, leading to urgent neurosurgery. After tumor removal, the patient's eating behaviors, weight, and growth but also puberty improved dramatically. One year later, a tumor remnant was found, necessitating targeted therapy.
This case underscores the possibility that cerebellar tumors can mimic ARFID-like syndrome, suggesting a neurological origin for the observed disordered eating behaviors. The marked improvement in eating patterns and growth after tumor removal strongly suggests a direct link between the cerebellar tumor and the patient's symptoms. Given the rarity and complexity of such cases, neurological evaluations, including brain magnetic resonance imaging, should be considered in any children and adolescents with eating disorder or severe disordered eating especially when growth is affected, or unusual symptoms are present.
level V, case report.
回避/限制性食物摄入障碍（ARFID）是《精神疾病诊断与统计手册》第5版（DSM-5）和《国际疾病分类》第11版（ICD-11）分类中最近才被认可的一种进食障碍类型。最近的功能神经影像学研究表明，进食障碍患者的小脑固有连接网络存在改变。进食障碍与中枢神经系统肿瘤之间的关联已有文献记载，但迄今为止，尚无研究将进食障碍与小脑病变联系起来。本病例报告介绍了一名患有ARFID症状和小脑肿瘤的13岁男孩，探讨了两者之间的潜在联系。
一名13岁青少年，有牙齿发育不全史，食物限制不断升级，严重腹痛，体重增加和身高增长受损，最初被诊断为ARFID。脑部磁共振成像显示一个巨大且有威胁性的小脑肿瘤，导致紧急神经外科手术。肿瘤切除后，患者的进食行为、体重、生长以及青春期都有了显著改善。一年后，发现有肿瘤残余，需要进行靶向治疗。
本病例强调了小脑肿瘤可能模仿ARFID样综合征的可能性，提示所观察到的饮食行为紊乱有神经学起源。肿瘤切除后进食模式和生长的显著改善强烈表明小脑肿瘤与患者症状之间存在直接联系。鉴于此类病例的罕见性和复杂性，对于任何患有进食障碍或严重饮食紊乱的儿童和青少年，尤其是在生长受到影响或出现异常症状时，应考虑进行包括脑部磁共振成像在内的神经学评估。
V级，病例报告。
