Finatto Arthur Nery, Meurens François, de Oliveira Costa Matheus
Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5E2, Canada.
Swine and Poultry Infectious Diseases Research Center, Faculty of Veterinary Medicine, University of Montreal, St. Hyacinthe, QC, J2S 2M2, Canada.
Vet Res. 2025 Mar 3;56(1):47. doi: 10.1186/s13567-025-01465-4.
Porcine β-defensins (pBDs) are cationic peptides that are classically associated with the innate immune system. These molecules yield both antimicrobial and immunomodulatory properties, as evidenced by various in vitro and animal trials. Researchers have revealed that enhancing pBD expression can be achieved through dietary components and gene editing techniques in pigs and porcine cell models. This state-of-the-art review aims to encapsulate the pivotal findings and progress made in the field of pBD over recent decades, with a specific emphasis on the biological role of pBD in infection control and its usage in clinical trials, thereby offering a new landscape of opportunities for research aimed at identifying prophylactic and therapeutic alternatives for both swine medicine and translational purposes.
猪β-防御素（pBDs）是一类与固有免疫系统经典相关的阳离子肽。这些分子具有抗菌和免疫调节特性，各种体外试验和动物试验都证明了这一点。研究人员发现，通过猪和猪细胞模型中的饮食成分和基因编辑技术可以提高pBD的表达。这篇最新综述旨在总结近几十年来pBD领域的关键发现和进展，特别强调pBD在感染控制中的生物学作用及其在临床试验中的应用，从而为旨在确定猪医学和转化目的的预防和治疗替代方案的研究提供新的机遇前景。
