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辉瑞-生物科技新冠疫苗加强针接种后发生的马约基环形毛细血管扩张性紫癜:巧合还是关联?

Purpura Annularis Telangiectodes of Majocchi Following a Booster Dose of the Pfizer-BioNTech COVID-19 Vaccine: Coincidence or Correlation?

作者信息

Al Salmi Amal, Al Shibli Abdullah, Al-Saadi Maimuna

机构信息

Dermatology, Al Buraimi Hospital, Al Buraimi, OMN.

Family Medicine, Oman Medical Specialty Board, Muscat, OMN.

出版信息

Cureus. 2025 Feb 1;17(2):e78336. doi: 10.7759/cureus.78336. eCollection 2025 Feb.

DOI:10.7759/cureus.78336
PMID:40034643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11874453/
Abstract

Following the widespread distribution of COVID-19 vaccines, a range of side effects have been reported globally. These effects range from mild reactions, such as injection site discomfort and fever, to rarer events like allergic responses. While most side effects have been mild and transient, their occurrence has prompted further investigation into their frequency, severity, and underlying mechanisms. Despite the generally favorable safety profile of current vaccines, ongoing research remains essential to ensuring their continued safety and effectiveness across diverse populations. In this paper, we present the case of a 25-year-old female diagnosed with purpura annularis telangiectodes of Majocchi following a booster dose of the Pfizer-BioNTech COVID-19 mRNA vaccine. Whether this represents a causal association or a coincidental occurrence warrants further investigation.

摘要

随着新冠病毒疫苗的广泛接种,全球范围内报告了一系列副作用。这些副作用从轻微反应,如注射部位不适和发热,到罕见的过敏反应等。虽然大多数副作用轻微且短暂,但它们的出现促使人们进一步研究其发生频率、严重程度及潜在机制。尽管目前的疫苗总体安全性良好,但持续研究对于确保其在不同人群中的持续安全性和有效性仍然至关重要。在本文中,我们报告了一例25岁女性在接种辉瑞 - 生物科技公司的新冠mRNA加强疫苗后被诊断为马约基环形毛细血管扩张性紫癜的病例。这是因果关联还是巧合事件,值得进一步研究。

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本文引用的文献

1
A Case of Purpura Annularis Telangiectodes of Majocchi after Anti-SARS-CoV-2 Pfizer-BioNTech Vaccine: Is There an Association?1例接种辉瑞-生物科技公司抗SARS-CoV-2疫苗后发生的马约基环形毛细血管扩张性紫癜:是否存在关联?
Vaccines (Basel). 2022 Nov 21;10(11):1972. doi: 10.3390/vaccines10111972.
2
Adverse cutaneous reactions reported post COVID-19 vaccination in Al Buraimi governorate, Sultanate of Oman.阿曼布赖米省报告的 COVID-19 疫苗接种后不良皮肤反应。
Dermatol Ther. 2022 Nov;35(11):e15820. doi: 10.1111/dth.15820. Epub 2022 Sep 23.
3
Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis.
新冠病毒疫苗接种后皮肤不良反应的全球流行率和临床表现:系统评价和荟萃分析。
J Eur Acad Dermatol Venereol. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Epub 2022 Jun 21.
4
Pigmented purpuric dermatosis after BNT162B2 mRNA COVID-19 vaccine administration.BNT162B2 mRNA新冠疫苗接种后出现色素性紫癜性皮病
J Cosmet Dermatol. 2022 Feb;21(2):435-437. doi: 10.1111/jocd.14607. Epub 2021 Nov 17.
5
Single-Center Clinico-Pathological Case Study of 19 Patients with Cutaneous Adverse Reactions Following COVID-19 Vaccines.19例COVID-19疫苗接种后皮肤不良反应患者的单中心临床病理病例研究
Dermatopathology (Basel). 2021 Sep 27;8(4):463-476. doi: 10.3390/dermatopathology8040049.
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Widespread purpura annularis telangiectodes following mRNA SARS-CoV-2 vaccine.接种新型冠状病毒mRNA疫苗后出现广泛的环状毛细血管扩张性紫癜。
J Eur Acad Dermatol Venereol. 2021 Nov;35(11):e719-e721. doi: 10.1111/jdv.17497. Epub 2021 Jul 21.
7
Pigmented Purpuric Dermatoses: A Complete Narrative Review.色素性紫癜性皮病:一篇完整的叙述性综述。
J Clin Med. 2021 May 25;10(11):2283. doi: 10.3390/jcm10112283.
8
Purpura annularis telangiectodes of Majocchi: case report and review of the literature.马约基环形毛细血管扩张性紫癜:病例报告及文献复习
Int J Dermatol. 2009 Oct;48(10):1129-33. doi: 10.1111/j.1365-4632.2009.04160.x.
9
Pigmented purpuric dermatoses: an overview.色素性紫癜性皮病:综述
Int J Dermatol. 2004 Jul;43(7):482-8. doi: 10.1111/j.1365-4632.2004.02213.x.