Zhang Fan, Xiang Yu, Ma Qiao, Guo E, Zeng Xiansheng
Wuhan University of Science and Technology, School of Medicine, Wuhan, China.
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
Front Oncol. 2024 Mar 18;14:1354859. doi: 10.3389/fonc.2024.1354859. eCollection 2024.
In the last decade, ferroptosis has received much attention from the scientific research community. It differs from other modes of cell death at the morphological, biochemical, and genetic levels. Ferroptosis is mainly characterized by non-apoptotic iron-dependent cell death caused by iron-dependent lipid peroxide excess and is accompanied by abnormal iron metabolism and oxidative stress. In recent years, more and more studies have shown that ferroptosis is closely related to the occurrence and development of lung diseases. COPD, asthma, lung injury, lung fibrosis, lung cancer, lung infection and other respiratory diseases have become the third most common chronic diseases worldwide, bringing serious economic and psychological burden to people around the world. However, the exact mechanism by which ferroptosis is involved in the development and progression of lung diseases has not been fully revealed. In this manuscript, we describe the mechanism of ferroptosis, targeting of ferroptosis related signaling pathways and proteins, summarize the relationship between ferroptosis and respiratory diseases, and explore the intervention and targeted therapy of ferroptosis for respiratory diseases.
在过去十年中，铁死亡受到了科研界的广泛关注。它在形态学、生物化学和遗传学水平上与其他细胞死亡模式不同。铁死亡主要特征是由铁依赖性脂质过氧化物过量导致的非凋亡性铁依赖性细胞死亡，并伴有铁代谢异常和氧化应激。近年来，越来越多的研究表明，铁死亡与肺部疾病的发生发展密切相关。慢性阻塞性肺疾病（COPD）、哮喘、肺损伤、肺纤维化、肺癌、肺部感染等呼吸系统疾病已成为全球第三大常见慢性病，给世界各地的人们带来了沉重的经济和心理负担。然而，铁死亡参与肺部疾病发生发展的确切机制尚未完全阐明。在本手稿中，我们描述了铁死亡的机制、铁死亡相关信号通路和蛋白质的靶向作用，总结了铁死亡与呼吸系统疾病之间的关系，并探讨了针对呼吸系统疾病的铁死亡干预和靶向治疗。
