Lieberman J A, Kane J M, Sarantakos S, Cole K, Howard A, Borenstein M, Novacenko H, Puig-Antich J
Am J Psychiatry. 1985 Jun;142(6):747-51. doi: 10.1176/ajp.142.6.747.
Obsessive-compulsive disorder and major depressive disorder are associated by several lines of evidence. To explore the possible relationship between the two disorders, the authors administered 1-mg dexamethasone suppression tests to 18 patients with obsessive-compulsive disorder and 51 patients with major depressive disorder. None of the obsessive-compulsive patients were classified as nonsuppressors on the basis of a 4:00 p.m. serum cortisol level, whereas 37% of the depressed patients were nonsuppressors. The mean cortisol levels of the two groups differed significantly. Factors that may influence hypothalamic-pituitary-adrenal function, such as age, depressive symptoms, and severity of illness, are discussed in light of these results.
多项证据表明强迫症和重度抑郁症存在关联。为探究这两种疾病之间可能的关系，作者对18名强迫症患者和51名重度抑郁症患者进行了1毫克地塞米松抑制试验。根据下午4点的血清皮质醇水平，没有一名强迫症患者被归类为非抑制者，而37%的抑郁症患者为非抑制者。两组的平均皮质醇水平有显著差异。根据这些结果，讨论了可能影响下丘脑 - 垂体 - 肾上腺功能的因素，如年龄、抑郁症状和疾病严重程度。
