Insel T R, Kalin N H, Guttmacher L B, Cohen R M, Murphy D L
Psychiatry Res. 1982 Apr;6(2):153-60. doi: 10.1016/0165-1781(82)90003-8.
The dexamethasone suppression test (DST) was administered to 16 obsessive-compulsive disorder (OCD) patients. Six of these patients (37.5%) had an abnormal DST response. There was a trend for patients with the DST abnormality to have higher depression rating scale scores and a higher incidence of family history of affective illness compared to DST suppressors. Although 7 of the 16 OCD patients met DSM-III criteria for major depressive disorder, in every case the affective symptoms were secondary to the primary obsessional illness. The relationship of the DST to the specificity of psychiatric diagnoses is discussed.
对16名强迫症（OCD）患者进行了地塞米松抑制试验（DST）。其中6名患者（37.5%）的DST反应异常。与DST抑制者相比，DST异常的患者有抑郁评定量表得分更高以及情感性疾病家族史发生率更高的趋势。虽然16名OCD患者中有7名符合DSM-III中重度抑郁症的标准，但在每种情况下，情感症状都是继发于原发性强迫性疾病。本文讨论了DST与精神科诊断特异性之间的关系。
