Wang Yaqin, Li Binbin, Jian Ching, Gagaoua Mohammed, Estévez Mario, Puolanne Eero, Ertbjerg Per
Department of Food and Nutrition Sciences, University of Helsinki, Helsinki, Finland.
Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Compr Rev Food Sci Food Saf. 2025 Mar;24(2):e70148. doi: 10.1111/1541-4337.70148.
Wooden breast (WB) is a multifactorial muscular abnormality resulting from the interplay between genetic predispositions for rapid growth, physiological stress, and anatomical impairments. This myopathy has been a persistent challenge in the poultry industry since its initial identification a decade ago. WB negatively impacts meat quality, leading to increased toughness and reduced nutritional value. Building on foundational research utilizing multiomics technologies, hypoxia-induced oxidative stress has been identified as a key early event driving the pathological processes of WB. This review provides a comprehensive overview and the state-of-the-art evidence on the pivotal role of oxidative stress in WB myopathy. It begins by examining the generation of reactive intermediates that induce oxidative damage and the host's defense mechanisms aimed at mitigating these threats. The discussion then focuses on the consequences of oxidative damage for mitochondria, protein and lipid oxidation, connective tissue remodeling, and inflammation-pathological hallmarks of WB-affected muscles. Additionally, the review highlights how oxidative stress influences satellite cell behavior, impairing the repair and regeneration of muscle tissues, a process implicated in WB. Finally, efforts to prevent or mitigate WB myopathy are summarized, with particular attention to potential intervention strategies targeting oxidative stress. These include innovative feed formulations and gut microbiota modulation, which show promise in alleviating the severity of the condition.
木鸡胸（WB）是一种多因素导致的肌肉异常，由快速生长的遗传易感性、生理应激和解剖学损伤之间的相互作用引起。自十年前首次发现以来，这种肌病一直是家禽业持续面临的挑战。WB对肉质有负面影响，导致肉的韧性增加和营养价值降低。基于利用多组学技术的基础研究，缺氧诱导的氧化应激已被确定为驱动WB病理过程的关键早期事件。本综述全面概述了氧化应激在WB肌病中的关键作用，并提供了最新证据。首先探讨了诱导氧化损伤的反应性中间体的产生以及宿主旨在减轻这些威胁的防御机制。然后讨论聚焦于氧化损伤对线粒体、蛋白质和脂质氧化、结缔组织重塑以及受WB影响肌肉的炎症病理特征的后果。此外，综述强调了氧化应激如何影响卫星细胞行为，损害肌肉组织的修复和再生，这一过程与WB有关。最后，总结了预防或减轻WB肌病的努力，特别关注针对氧化应激的潜在干预策略。这些策略包括创新的饲料配方和肠道微生物群调节，它们在减轻病情严重程度方面显示出前景。
