膝关节骨关节炎患者的关节囊干细胞功能和组织组成与症状及影像学严重程度相关。
Capsular stem cell function and tissue composition are associated with symptoms and radiographic severity in people with knee osteoarthritis.
作者信息
Campbell T Mark, Feibel Robert, Dilworth Jeffrey, Laneuville Odette, Trudel Guy
机构信息
Department of Physical Medicine and Rehabilitation, Elisabeth Bruyère Hospital, 43 Bruyère Street, Ottawa, Ontario K1N 5C8, Canada.
Division of Orthopedic Surgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON, Canada.
出版信息
Ther Adv Musculoskelet Dis. 2025 Mar 3;17:1759720X251321941. doi: 10.1177/1759720X251321941. eCollection 2025.
BACKGROUND
Osteoarthritis (OA) is associated with lost range of motion in the affected joint(s). Evidence suggests that this may be due to increased activity of posterior capsule fibroblasts, cells in turn derived from mesenchymal stromal cells (MSCs).
OBJECTIVES
To test the hypotheses that (1) MSCs are more numerous in the posterior capsule of patients with knee flexion contracture (FC) and (2) in OA participants with knee FC, the MSC population in the posterior capsule differentiates toward a fibrotic phenotype. In order to complete these objectives, we looked for associations between capsule histologic and MSC outcomes with clinical outcomes.
DESIGN
Cross-sectional translational research design using data from the Ottawa Knee Osteoarthritis (OKOA) database.
METHODS
A total of 71 OKOA database participants and their relevant clinical and laboratory outcomes were included. Associations were first tested with bivariate correlation, then for < 0.10, tested using a linear model.
RESULTS
No lab-based differences between FC and no-FC groups we discovered. In the posterior capsule, there was an association between knee flexion and adipogenic capacity ( = 0.001), osteogenic capacity ( < 0.001), KL grade and percent "other" (mainly neurovascular) tissue ( = 0.039), visual analog scale pain, and percent fibrous tissue ( = 0.014). For the anterior capsule, there was an association between knee flexion ( = 0.002) and extension ( = 0.005) with MSC enumeration, KL grade with MSC fibrogenic capacity ( = 0.002), and Knee Injury and Osteoarthritis Outcome Score quality of life with chondrogenic capacity ( < 0.001).
CONCLUSION
Joint capsule composition, MSC enumeration, and function were associated with important clinical OA outcomes. These findings suggest that the entire joint capsule may play an important role in OA-related morbidity and progression and could represent an underappreciated target for OA treatment.
背景
骨关节炎（OA）与受累关节活动范围丧失有关。有证据表明，这可能是由于后关节囊成纤维细胞活性增加，而成纤维细胞又源自间充质基质细胞（MSCs）。
目的
检验以下假设：（1）膝关节屈曲挛缩（FC）患者后关节囊中MSCs数量更多；（2）在伴有膝关节FC的OA参与者中，后关节囊中的MSC群体向纤维化表型分化。为了实现这些目标，我们寻找了关节囊组织学和MSC结果与临床结果之间的关联。
设计
采用渥太华膝关节骨关节炎（OKOA）数据库的数据进行横断面转化研究设计。
方法
共纳入71名OKOA数据库参与者及其相关临床和实验室结果。首先用双变量相关性检验关联，然后对于P<0.10的情况，使用线性模型进行检验。
结果
我们未发现FC组和非FC组之间基于实验室的差异。在后关节囊中，膝关节屈曲与成脂能力（P = 0.001）、成骨能力（P<0.001）、KL分级与“其他”（主要是神经血管）组织百分比（P = 0.039）、视觉模拟量表疼痛以及纤维组织百分比（P = 0.014）之间存在关联。对于前关节囊，膝关节屈曲（P = 0.002）和伸展（P = 0.005）与MSC计数之间存在关联，KL分级与MSC纤维化能力（P = 0.002）之间存在关联，膝关节损伤和骨关节炎结果评分生活质量与软骨形成能力（P<0.001）之间存在关联。
结论
关节囊组成、MSC计数和功能与重要的临床OA结果相关。这些发现表明，整个关节囊可能在OA相关的发病率和进展中起重要作用，并且可能是OA治疗中一个未被充分重视的靶点。
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