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妊娠期噬血细胞性淋巴组织细胞增生症:1例病例报告及文献复习

Haemophagocytic lymphohistiocytosis during pregnancy: a case presentation and literature review.

作者信息

Fávero Vanraes Larissa, Beckers Veerle, Van Berkel Kim, Gucciardo Leonardo, Faron Gilles

机构信息

Department of Gynaecology and Obstetrics, Vrije Universiteit Brussel, Brussels Health Campus, Brussels, Belgium.

Division of Haematology, Department of Internal Medicine, Vrije Universiteit Brussel, Brussels Health Campus, Brussels, Belgium.

出版信息

Case Rep Perinat Med. 2022 Mar 4;11(1):20210004. doi: 10.1515/crpm-2021-0004. eCollection 2022 Jan.

DOI:10.1515/crpm-2021-0004
PMID:40041215
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11800670/
Abstract

OBJECTIVES

Haemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disorder of the immune system that typically occurs in the paediatric population. Diagnosing this rare disease in the adult population is challenging, particularly during pregnancy.

CASE PRESENTATION

We present a case of a gravid patient developing HLH at week 13 of gestation undergoing a medical termination of pregnancy at 27 weeks due to anhydramnios and associated stopped foetal growth.

CONCLUSIONS

Disease triggers could vary from a simple viral infection to the pregnancy as such causing the disorder. Treatment should benefit the mother and limit the foetal harm.

摘要

目的

噬血细胞性淋巴组织细胞增生症(HLH)是一种潜在致命的免疫系统疾病,通常发生于儿科人群。在成人中诊断这种罕见疾病具有挑战性,尤其是在孕期。

病例报告

我们报告一例妊娠患者,在妊娠13周时发生HLH,因羊水过少及相关胎儿生长停止,于27周时接受了人工流产。

结论

疾病触发因素可能从简单的病毒感染到妊娠本身引发该疾病。治疗应使母亲受益并减少对胎儿的伤害。

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本文引用的文献

1
Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report.妊娠相关性噬血细胞性淋巴组织细胞增生症:一例报告
J Obstet Gynaecol India. 2020 Oct;70(5):390-392. doi: 10.1007/s13224-019-01286-4. Epub 2019 Nov 7.
2
Pregnancy-induced haemophagocytic lymphohistiocytosis.妊娠相关性噬血细胞性淋巴组织细胞增生症
J Intensive Care Soc. 2020 Feb;21(1):87-91. doi: 10.1177/1751143718809678. Epub 2018 Oct 31.
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Adult haemophagocytic lymphohistiocytosis: a Review.成人噬血细胞性淋巴组织细胞增生症:综述
QJM. 2020 Jan 14. doi: 10.1093/qjmed/hcaa011.
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Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.胎母微嵌合体:子痫前期的难题。
Front Immunol. 2019 Mar 29;10:659. doi: 10.3389/fimmu.2019.00659. eCollection 2019.
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Hemophagocytic Lymphohistiocytosis in Pregnancy: A Case Series and Review of the Current Literature.妊娠期噬血细胞性淋巴组织细胞增生症:病例系列及当前文献综述
Case Rep Obstet Gynecol. 2019 Feb 12;2019:9695367. doi: 10.1155/2019/9695367. eCollection 2019.
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Pregnancy-associated hemophagocytic lymphohistiocytosis secondary to NK/T cells lymphoma: A case report and literature review.自然杀伤/T细胞淋巴瘤继发妊娠相关噬血细胞性淋巴组织细胞增生症:一例报告及文献复习
Medicine (Baltimore). 2017 Nov;96(47):e8628. doi: 10.1097/MD.0000000000008628.
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Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.可溶性白细胞介素-2受体是成人噬血细胞性淋巴组织细胞增生症的一项敏感诊断检测。
Blood Adv. 2017 Dec 6;1(26):2529-2534. doi: 10.1182/bloodadvances.2017012310. eCollection 2017 Dec 12.
8
Hepatitis during pregnancy: A case of hemophagocytic lymphohistiocytosis.妊娠期肝炎:1例噬血细胞性淋巴组织细胞增生症病例
Clin Res Hepatol Gastroenterol. 2018 Jun;42(3):e49-e55. doi: 10.1016/j.clinre.2017.10.007. Epub 2017 Nov 24.
9
Haemophagocytic lymphohistiocytosis presenting as HELLP syndrome: a diagnostic and therapeutic challenge.以HELLP综合征表现的噬血细胞性淋巴组织细胞增生症:诊断与治疗挑战
BMJ Case Rep. 2017 Apr 22;2017:bcr-2017-219516. doi: 10.1136/bcr-2017-219516.
10
Hemophagocytic syndrome secondary to tuberculosis at 24-week gestation.妊娠24周时继发于肺结核的噬血细胞综合征
Int J Mycobacteriol. 2017 Jan-Mar;6(1):108-110. doi: 10.4103/ijmy.ijmy_14_17.