Fernández Alexandra Arteaga, de Velasco Pérez David Fernández, Fournier M C Jiménez, Moreno Del Prado J C, Torras B Paraíso, Cañete Palomo M L
Department of Obstetrics and Gynecology, Virgen de la Salud Hospital, Toledo, Spain.
Department of Internal Medicine, Fundación Alcorcón Universitary Hospital, Alcorcón, Madrid, Spain.
Int J Mycobacteriol. 2017 Jan-Mar;6(1):108-110. doi: 10.4103/ijmy.ijmy_14_17.
Hemophagocytic syndrome is a life-threatening disease characterized by the uncontrolled activation of macrophages, resulting in hemophagocytosis of blood cells in the bone marrow. A 20-year-old gravida at 23-week and 5-day gestation was admitted to hospital to evaluate fever up to 104°F of unknown origin, moderate cytopenia, and elevated levels of liver enzymes. Bone marrow biopsy confirmed hemophagocytic syndrome, and polymerase chain reaction came back positive for Mycobacterium tuberculosis. Supportive care and tuberculosis treatment resulted in clinical improvement. At 27 weeks and 5 days, premature rupture of the membranes occurred, and because of the high probability of reactivating the hemophagocytic syndrome, a cesarean section was performed at 29-week and 2-day gestation. Hemophagocytic syndrome is an uncommon disease which rarely appears during pregnancy. Early diagnosis and treatment can save both maternal and fetal lives.
噬血细胞综合征是一种危及生命的疾病，其特征为巨噬细胞不受控制地激活，导致骨髓中血细胞被噬血细胞作用吞噬。一名孕23周5天的20岁孕妇因不明原因发热至104°F、中度血细胞减少和肝酶水平升高入院。骨髓活检确诊为噬血细胞综合征，聚合酶链反应结果显示结核分枝杆菌呈阳性。支持性治疗和抗结核治疗使病情得到临床改善。孕27周5天时发生胎膜早破，由于噬血细胞综合征复发的可能性很高，遂于孕29周2天行剖宫产。噬血细胞综合征是一种罕见疾病，在孕期很少出现。早期诊断和治疗可挽救母婴生命。
