一名早产儿的胆汁淤积和先天性神经母细胞瘤：病例报告
Cholestasis and congenital neuroblastoma in a preterm neonate: a case report.
作者信息
Puvabanditsin Surasak, Guillermo Melissa, Cheng Yisha, Sudol Olga, Mehta Rajeev
机构信息
Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, New Brunswick, NJ 08903, USA.
Department of Pediatrics, Rutgers Robert Wood Johnson, Medical School, New Brunswick, NJ, USA.
出版信息
Case Rep Perinat Med. 2022 Dec 19;12(1):20210089. doi: 10.1515/crpm-2021-0089. eCollection 2023 Jan.
OBJECTIVES
Neuroblastoma (NB) is one of the most common tumor during perinatal period. The clinical features of NB occurring in fetuses and neonates differ from that in the older age groups. Frequently, Congenital neuroblastomas are incidentally detected prenatally. Clinical presentations of NBs in neonates are highy variable.
CASE PRESENTATION
A 24-day old preterm 32 weeks' gestation male neonate developed cholestasis that lead to the diagnosis of stage MS neuroblastoma. There was no NB primary site identified.
CONCLUSIONS
To the best of our knowledge, this is the first case report of metastatic NB (Stage MS) in a preterm neonate presenting with cholestsis but without any identifiable adrenal or extra-adrenal primary.
目的
神经母细胞瘤（NB）是围产期最常见的肿瘤之一。胎儿和新生儿期发生的NB的临床特征与年龄较大的人群不同。先天性神经母细胞瘤常于产前偶然发现。新生儿NB的临床表现高度多变。
病例报告
一名孕32周早产的24日龄男婴出现胆汁淤积，进而诊断为MS期神经母细胞瘤。未发现NB的原发部位。
结论
据我们所知，这是首例以胆汁淤积为表现、无任何可识别的肾上腺或肾上腺外原发灶的早产新生儿转移性NB（MS期）病例报告。
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