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Why does stage 4s neuroblastoma regress spontaneously?

作者信息

Pritchard J, Hickman J A

机构信息

Department of Haematology and Oncology, Hospital for Children NHS Trust, London, UK.

出版信息

Lancet. 1994 Sep 24;344(8926):869-70. doi: 10.1016/s0140-6736(94)92834-7.

DOI:10.1016/s0140-6736(94)92834-7
PMID:7916408
Abstract
摘要

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Why does stage 4s neuroblastoma regress spontaneously?为什么4s期神经母细胞瘤会自发消退?
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Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas.MYCN/c-MYC 的转录活性差异与神经母细胞瘤的自发消退或恶性进展相关。
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Congenital stage 1 neuroblastoma evolved into stage 4s.先天性1期神经母细胞瘤进展为4s期。
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Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.凋亡抑制蛋白bcl-2在神经母细胞瘤中的表达与不良组织学及N-myc扩增相关。
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[Receptor tyrosine kinase KIT may regulate expression of genes involved in spontaneous regression of neuroblastoma].
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Molecular basis of spontaneous regression of neuroblastoma: role of neurotrophic signals and genetic abnormalities.神经母细胞瘤自发消退的分子基础:神经营养信号和基因异常的作用
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Proteomics-based identification of spontaneous regression-associated proteins in neuroblastoma.基于蛋白质组学的神经母细胞瘤自发消退相关蛋白的鉴定。
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Inverse relationship between trk expression and N-myc amplification in human neuroblastomas.人神经母细胞瘤中trk表达与N - myc扩增之间的负相关关系。
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Detection of N-myc gene amplification in bone marrow specimen of stage IV neuroblastoma patients.
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Spontaneous regression of metastases including meningeal metastasis after gross resection of primary tumor in an infant with stage 4 neuroblastoma.一名患有4期神经母细胞瘤的婴儿在原发性肿瘤大体切除术后,转移灶包括脑膜转移灶出现自发消退。
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