Mazumder Sarmistha, Das Tiasa, Vankayala Raviraj
Center for Medical Technologies, Indian Institute of Technology Jodhpur 342030 Rajasthan India.
Department of Bioscience & Bioengineering, Indian Institute of Technology Jodhpur 342030 Rajasthan India
RSC Adv. 2025 Mar 4;15(9):6984-6993. doi: 10.1039/d4ra08914f. eCollection 2025 Feb 26.
Metal oxide nanoparticles offer capabilities for cancer therapeutics, but their applicability is often jeopardized due to toxicity hurdles. To tackle this problem, in this study, we have synthesized europium decorated cuprous oxide nanoparticles (Eu-CuO NPs) a facile ultrasonic-assisted method. Surface decoration of nanoparticles is an effective strategy to tailor their physicochemical and biological properties. The decorated nanoparticles were found to possess improved stability, superior biocompatibility and enhanced photothermal properties than the undecorated pristine nanoparticles (CuO NPs). studies validated the capacity of the decorated nanoparticles to regulate the production of reactive oxygen species (ROS) and in turn combat the inherent toxicity of cuprous nanoparticles. By controlling the ROS dynamics and decreasing inadvertent toxic effects minimize possibilities of higher toxicity enabling this innovative strategy to potentially transform into an effective platform for drug delivery systems.
金属氧化物纳米颗粒为癌症治疗提供了多种能力，但其适用性常常因毒性障碍而受到影响。为了解决这个问题，在本研究中，我们采用一种简便的超声辅助方法合成了铕修饰的氧化亚铜纳米颗粒（Eu-CuO NPs）。纳米颗粒的表面修饰是调整其物理化学和生物学性质的有效策略。结果发现，与未修饰的原始纳米颗粒（CuO NPs）相比，修饰后的纳米颗粒具有更高的稳定性、更好的生物相容性和更强的光热性能。研究证实了修饰后的纳米颗粒能够调节活性氧（ROS）的产生，进而对抗氧化亚铜纳米颗粒的固有毒性。通过控制ROS动态并减少意外的毒性作用，将高毒性的可能性降至最低，使这一创新策略有可能转化为药物递送系统的有效平台。
