Songviriyavithaya Phichit, Wipattanakitcharoen Aschariya, Pikul Niparat, Wannigama Dhammika Leshan, Kanjanabuch Talerngsak
Division of Nephrology, Department of Medicine of Amnatcharoen Hospital, Amnatcharoen, Thailand.
Division of Nephrology, Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Med Mycol Case Rep. 2025 Feb 11;47:100696. doi: 10.1016/j.mmcr.2025.100696. eCollection 2025 Mar.
This report documents the first human case of colonization in a peritoneal dialysis catheter, identified through DNA sequencing after a 52-year-old man observed brownish particles within his catheter. Despite the absence of peritonitis symptoms, prompt catheter removal and antifungal therapy successfully resolved the infection. Fungal cultures revealed cerebriform (brain-like) colonies, confirmed as using multi-targeted molecular diagnostics. A wet contamination event three weeks earlier was identified as the likely source. This case underscores the importance of recognizing intraluminal particles as an indicator of fungal colonization and highlights the critical role of timely intervention and advanced diagnostics in preventing fungal peritonitis.
本报告记录了首例腹膜透析导管定植的人类病例，该病例是在一名52岁男性观察到其导管内有褐色颗粒后，通过DNA测序确定的。尽管没有腹膜炎症状，但及时拔除导管和抗真菌治疗成功解决了感染问题。真菌培养显示为脑状菌落，经多靶点分子诊断得以确认。三周前的一次湿污染事件被确定为可能的源头。该病例强调了将管腔内颗粒识别为真菌定植指标的重要性，并突出了及时干预和先进诊断在预防真菌性腹膜炎中的关键作用。
