Boyle Patricia A, Wang Tianhao, Mottola Gary, Stewart Chris, Wilson Robert S, Bennett David A, Yu Lei
Rush University Medical Center, Rush Alzheimer's Disease Center, Chicago, Illinois, USA.
Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.
Alzheimers Dement. 2025 Mar;21(3):e14544. doi: 10.1002/alz.14544.
The association of scam susceptibility with the timing of Alzheimer's disease (AD) dementia onset is unknown.
One thousand ninety-two older adults without dementia underwent assessments of scam susceptibility and annual clinical evaluations to document incident AD dementia. Accelerated failure time models examined the relation of scam susceptibility with dementia onset.
During a mean of 5 years of follow-up (standard deviation = 3.1), 188 individuals (17%) were diagnosed with incident AD dementia. A higher level of scam susceptibility was associated with a considerably earlier dementia onset ( = -0.039; 95% confidence interval: -0.061, -0.017); those with a high level of susceptibility developed AD dementia at a mean age of 90.9 years compared to 98.2 for those with a low level. Results persisted after controlling for global cognition, sex, and education.
Scam susceptibility is associated with a markedly earlier onset of AD dementia. Assessment of susceptibility may facilitate early identification of individuals at risk of developing dementia.
We examined whether scam susceptibility among older adults is associated with an accelerated onset of Alzheimer's disease dementia. Participants came from a large ongoing cohort study of aging. Scam susceptibility was assessed using a validated measure. Scam susceptibility was associated with a marked acceleration in dementia onset. Assessment of susceptibility may facilitate early identification of dementia.
诈骗易感性与阿尔茨海默病（AD）痴呆症发病时间之间的关联尚不清楚。
1092名无痴呆症的老年人接受了诈骗易感性评估和年度临床评估，以记录AD痴呆症的发病情况。加速失效时间模型研究了诈骗易感性与痴呆症发病之间的关系。
在平均5年的随访期间（标准差=3.1），188人（17%）被诊断为新发AD痴呆症。较高水平的诈骗易感性与明显更早的痴呆症发病相关（β=-0.039；95%置信区间：-0.061，-0.017）；易感性高的人患AD痴呆症的平均年龄为90.9岁，而低易感性的人则为98.2岁。在控制了整体认知、性别和教育程度后，结果依然成立。
诈骗易感性与AD痴呆症的明显更早发病相关。对易感性的评估可能有助于早期识别有患痴呆症风险的个体。
我们研究了老年人的诈骗易感性是否与阿尔茨海默病痴呆症的加速发病有关。参与者来自一项正在进行的大型衰老队列研究。使用经过验证的测量方法评估诈骗易感性。诈骗易感性与痴呆症发病的显著加速有关。对易感性的评估可能有助于痴呆症的早期识别。
