Chihara G
Gan To Kagaku Ryoho. 1985 Jun;12(6):1196-209.
The most important target in pharmaceutical therapy against cancer is complete suppression of metastases and recurrence after curative surgical operation. It is fundamentally, a growth inhibition and regression of small number of autochthonous tumors scattering in the host, and coexistence between tumor and host is also important. As immunosuppressive anticancer drugs have detrimental effects for patients in such cases, application of strong immunopotentiators such as lentinan should be expected. Lentinan showed a prominent effect on suppression of metastases in experimental systems of clinical models using MH-134 hepatoma, Madison-109 lung carcinoma and DBA/2.MC.CS-1 fibrosarcoma. Suppression of carcinogenesis may be considered as one of experimental methods to prevent metastases in a viewpoint of regression of small number of autochthonous tumor cells. Lentinan given at suitable timing and schedule showed marked prophylactic effect on chemical and viral carcinogenesis. Mode of action of lentinan as T-oriented adjuvant in its antitumor and metastases-inhibitory effects is also discussed. Considering excellent end-point results of Phase III with advanced and recurrent gastrointestinal cancer, lentinan is the most hopeful substance to prevent micrometastases.
抗癌药物治疗的最重要目标是在根治性手术后完全抑制转移和复发。从根本上讲，这是对宿主中散在的少量原发肿瘤的生长抑制和消退，肿瘤与宿主的共存也很重要。由于免疫抑制抗癌药物在这种情况下对患者有有害影响，因此应期望应用如香菇多糖等强效免疫增强剂。香菇多糖在使用MH - 134肝癌、Madison - 109肺癌和DBA/2.MC.CS - 1纤维肉瘤的临床模型实验系统中对转移抑制显示出显著效果。从少量原发肿瘤细胞消退的角度来看，抑制致癌作用可被视为预防转移的实验方法之一。在合适的时间和方案给予香菇多糖对化学和病毒致癌作用显示出显著的预防效果。还讨论了香菇多糖作为T细胞导向佐剂在其抗肿瘤和转移抑制作用中的作用方式。考虑到晚期和复发性胃肠道癌III期的优异终点结果，香菇多糖是预防微转移最有希望的物质。
