Pratikna Aldhimas Marthsyal, Rivai M Iqbal, Suswita Rini, Putra Andani Eka, Rachman Irwan Abdul, Suchitra Avit
Department of Surgery, Dr. M. Djamil General Hospital, Universitas Andalas, Padang, Indonesia.
Department of Microbiology, Universitas Andalas, Padang, Indonesia.
Ann Coloproctol. 2025 Feb;41(1):47-56. doi: 10.3393/ac.2024.00346.0049. Epub 2025 Feb 26.
This study aimed to determine the effect of tumor resection on dysbiosis of the intestinal microbiota in patients with right-sided colon cancer.
This study utilized a longitudinal design to explore the outcomes of patients diagnosed with right-sided colon cancer who underwent surgical resection at Dr. M. Djamil General Hospital from July to December 2023. We excluded patients with a documented history of comorbidities, specifically those affecting the digestive system. To compare the microbiota (genus and phylum) between patients with right-sided colon cancer and the control group, we conducted bivariate analyses using the independent t-test or Mann-Whitney test. Furthermore, we employed the dependent t-test or Wilcoxon test to assess changes in the dysbiosis of the microbiota (genus and phylum) before and after resection. A P-value of <0.05 was considered statistically significant.
This study included a total of 21 patients diagnosed with right-sided colon cancer. In the control group, Bacteroidetes constituted the highest proportion of intestinal microbiota, accounting for 56.34%. Prior to tumor resection, the intestinal microbiota of patients exhibited Proteobacteria as the predominant phylum, representing 52.97%. Following tumor resection, Bacteroidetes remained the most prevalent, comprising 50.9% of the intestinal microbiota. Significant variations in the levels of Proteobacteria, Verrucomicrobia, and Cyanobacteria/Chloroplast were observed in the intestinal microbiota of patients with right-sided colorectal cancer before and after tumor excision (all P=0.001).
The microbiome of patients with right-sided colorectal cancer differed significantly from that of the control group. However, following tumor resection, the microbiome composition of these patients became more similar to that observed in the control group.
本研究旨在确定肿瘤切除对右侧结肠癌患者肠道微生物群失调的影响。
本研究采用纵向设计，以探究2023年7月至12月在M. 贾米尔综合医院接受手术切除的右侧结肠癌患者的治疗结果。我们排除了有合并症记录的患者，特别是那些影响消化系统的合并症患者。为了比较右侧结肠癌患者与对照组之间的微生物群（属和门），我们使用独立t检验或曼-惠特尼检验进行双变量分析。此外，我们采用配对t检验或威尔科克森检验来评估切除前后微生物群（属和门）失调的变化。P值<0.05被认为具有统计学意义。
本研究共纳入21例诊断为右侧结肠癌的患者。在对照组中，拟杆菌门在肠道微生物群中占比最高，为56.34%。在肿瘤切除前，患者的肠道微生物群以变形菌门为主，占52.97%。肿瘤切除后，拟杆菌门仍然最为普遍，占肠道微生物群的50.9%。在右侧结肠癌患者肿瘤切除前后的肠道微生物群中，变形菌门、疣微菌门和蓝藻/叶绿体的水平存在显著差异（均P=0.001）。
右侧结肠癌患者的微生物组与对照组有显著差异。然而，肿瘤切除后，这些患者的微生物组组成变得更类似于对照组中观察到的情况。
