基于血液检测乳腺癌的验证凸显了跨人群验证的重要性。 - Suppr

Suppr

超能文献

Validation of blood-based detection of breast cancer highlights importance for cross-population validation.

作者信息

Theeuwes Bente, Ambatipudi Srikant, Herceg Zdenko, Herzog Chiara Maria, Widschwendter Martin

机构信息

European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.

Institute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria.

出版信息

Nat Commun. 2025 Mar 5;16(1):2164. doi: 10.1038/s41467-025-57265-z.

DOI:10.1038/s41467-025-57265-z

PMID:40044645

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11882885/

Abstract

摘要

相似文献

Validation of blood-based detection of breast cancer highlights importance for cross-population validation.基于血液检测乳腺癌的验证凸显了跨人群验证的重要性。

Nat Commun. 2025 Mar 5;16(1):2164. doi: 10.1038/s41467-025-57265-z.

The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review.循环肿瘤 DNA 血液生物标志物用于癌症早期检测的证据基础：系统绘图综述。

BMC Cancer. 2017 Oct 23;17(1):697. doi: 10.1186/s12885-017-3693-7.

Clinical Validation of a Circulating Tumor DNA-Based Blood Test to Screen for Colorectal Cancer.一种基于循环肿瘤DNA的血液检测用于筛查结直肠癌的临床验证

JAMA. 2025 Jun 2. doi: 10.1001/jama.2025.7515.

Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal.纳入血液检测趋势用于癌症检测的临床预测模型：系统评价、荟萃分析和批判性评估

JMIR Cancer. 2025 Jun 27;11:e70275. doi: 10.2196/70275.

Prognostic Tools for Older Women with Breast Cancer: A Systematic Review.老年女性乳腺癌预后工具：系统评价。

Medicina (Kaunas). 2023 Aug 30;59(9):1576. doi: 10.3390/medicina59091576.

Development and validation of an MRI spatiotemporal interaction model for early noninvasive prediction of neoadjuvant chemotherapy response in breast cancer: a multicentre study.用于乳腺癌新辅助化疗反应早期无创预测的MRI时空相互作用模型的开发与验证：一项多中心研究

EClinicalMedicine. 2025 Jun 12;85:103298. doi: 10.1016/j.eclinm.2025.103298. eCollection 2025 Jul.

Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts.19个队列中绝经前乳腺癌风险预测模型的开发与验证

Breast Cancer Res. 2025 May 1;27(1):67. doi: 10.1186/s13058-025-02031-8.

An explainable-by-design end-to-end AI framework based on prototypical part learning for lesion detection and classification in Digital Breast Tomosynthesis images.一种基于原型部分学习的可设计解释的端到端人工智能框架，用于数字乳腺断层合成图像中的病变检测和分类。

Comput Struct Biotechnol J. 2025 Jun 10;27:2649-2660. doi: 10.1016/j.csbj.2025.06.008. eCollection 2025.

A High-Sensitivity, Bluetooth-Enabled PCB Biosensor for HER2 and CA15-3 Protein Detection in Saliva: A Rapid, Non-Invasive Approach to Breast Cancer Screening.一种用于唾液中HER2和CA15-3蛋白检测的高灵敏度、支持蓝牙的印刷电路板生物传感器：一种快速、非侵入性的乳腺癌筛查方法。

Biosensors (Basel). 2025 Jun 15;15(6):386. doi: 10.3390/bios15060386.

Co-development of breast cancer health promotion educational materials for ethnically diverse women working with hairdressing and beauty salons: BELONG study.合作开发针对在美发沙龙工作的不同族裔女性的乳腺癌健康促进教育材料：BELONG 研究。

Br J Gen Pract. 2024 Jun 20;74(suppl 1):bjgp24X738165. doi: 10.3399/bjgp24X738165.

本文引用的文献

Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients.非裔美国、欧裔美国和肯尼亚患者的乳腺肿瘤中的特定人群突变模式。

Cancer Res Commun. 2023 Nov 7;3(11):2244-2255. doi: 10.1158/2767-9764.CRC-23-0165.

DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment.数量性状位点（mQTLs）处的DNA甲基化随细胞类型和非遗传因素而变化，可能会改善乳腺癌风险评估。

NPJ Precis Oncol. 2023 Sep 27;7(1):99. doi: 10.1038/s41698-023-00452-2.

A multiplex blood-based assay targeting DNA methylation in PBMCs enables early detection of breast cancer.一种基于多聚体血液的检测方法，通过检测外周血单核细胞中的 DNA 甲基化，可实现对乳腺癌的早期检测。

Nat Commun. 2023 Aug 7;14(1):4724. doi: 10.1038/s41467-023-40389-5.

The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.WID-BC-index 基于宫颈样本中的 DNA 甲基化，识别出原发性预后不良的乳腺癌女性。

Nat Commun. 2022 Feb 1;13(1):449. doi: 10.1038/s41467-021-27918-w.

Circulating cell-free DNA-based methylation patterns for breast cancer diagnosis.基于循环游离DNA甲基化模式的乳腺癌诊断

NPJ Breast Cancer. 2021 Aug 16;7(1):106. doi: 10.1038/s41523-021-00316-7.

Incidence, Characteristics, and Outcomes of Interval Breast Cancers Compared With Screening-Detected Breast Cancers.与筛查检出的乳腺癌相比，间隔期乳腺癌的发病情况、特征和结局。

JAMA Netw Open. 2020 Sep 1;3(9):e2018179. doi: 10.1001/jamanetworkopen.2020.18179.

Personalized early detection and prevention of breast cancer: ENVISION consensus statement.乳腺癌个体化早期检测和预防：ENVISION 共识声明。

Nat Rev Clin Oncol. 2020 Nov;17(11):687-705. doi: 10.1038/s41571-020-0388-9. Epub 2020 Jun 18.

Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies.血液 DNA 甲基化与乳腺癌风险：四项前瞻性队列研究的荟萃分析。

Breast Cancer Res. 2019 May 17;21(1):62. doi: 10.1186/s13058-019-1145-9.

Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis.氧化应激通过炎症、自身免疫和纤维化在全身性硬皮病发病机制中的作用。

Redox Biol. 2019 Jul;25:101122. doi: 10.1016/j.redox.2019.101122. Epub 2019 Jan 25.

Methylation patterns in serum DNA for early identification of disseminated breast cancer.血清 DNA 甲基化模式可早期识别播散性乳腺癌。

Genome Med. 2017 Dec 22;9(1):115. doi: 10.1186/s13073-017-0499-9.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验