Grenier B, Viarme F, Roumiantzeff M, Xueref C, Demont F
Arch Fr Pediatr. 1985 Apr;42(4):321-3.
An inactivated trivalent poliovirus vaccine, prepared on simian line-cells (Vero cells), has been injected in 3 doses one month apart in 36 infants, 2 to 11 months old (30 of whom were 2 to 6 months old) to determine its tolerance and antigenic efficacy. Each dose contained 40, 8 and 32 antigenic D units for the 3 types respectively. DPT vaccine was injected simultaneously in another part of the body. Before beginning the immunization program, 20 infants had significant titers of antibodies against the 3 types of poliovirus; Only 6 were triple negative. One month after the second dose of vaccine, all the infants had significant titers of antibodies against the 3 types; these titers have not been significantly enhanced one month after the third dose. Two doses of the inactivated vaccine one month apart induced a satisfactory serologic response in spite of the presence of serum maternally transmitted antibodies. There were no adverse reactions.
一种在猴肾细胞（Vero细胞）上制备的三价灭活脊髓灰质炎疫苗，以3剂、间隔1个月的方式注射给了36名2至11个月大的婴儿（其中30名是2至6个月大），以确定其耐受性和抗原效力。每剂分别含有针对3种类型的40、8和32个抗原D单位。白百破疫苗在身体的另一部位同时注射。在开始免疫程序之前，20名婴儿对3种脊髓灰质炎病毒有显著的抗体滴度；只有6名是三阴性。在第二剂疫苗接种后1个月，所有婴儿对3种类型都有显著的抗体滴度；在第三剂疫苗接种后1个月，这些滴度没有显著提高。尽管存在母传血清抗体，但间隔1个月的两剂灭活疫苗仍诱导了令人满意的血清学反应。没有不良反应。
