Kwon JinAh, Byon Jung Hee, Ko Byung Kyun, Kim Jin Sung, Bang Minseo
Department of Surgery, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, Korea.
Department of Radiology, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, Korea.
BMC Surg. 2025 Mar 5;25(1):91. doi: 10.1186/s12893-025-02821-z.
The cosmetic outcomes of breast-conserving surgery (BCS) have recently gained increasing attention, and surgeons are exploring the use of the acellular dermal matrix (ADM) as a safe and effective method of breast reconstruction. This study evaluated the clinical progress of patients with breast cancer following the application of sheet-type ADM for breast reconstruction after BCS.
This retrospective study included 137 patients who underwent BCS using ADM at a single center between October 2019 and October 2021. During surgery, sheet-type ADM was folded and inserted into the excised defects. Complications and cancer recurrence were evaluated during surveillance follow-up until December 2023, and maintenance of the inserted ADM was quantitatively compared using volume analysis of the first and last follow-up computed tomography (CT).
Of the 137 evaluated patients, 16 (11.6%) had minor complications, and 17 (12.4%) underwent biopsy during the surveillance period. One patient was diagnosed with recurrence. ADM volume was measured in 55 patients. The mean volume reduction between the first and last CT scans was 1.81 ± 2.06 cm³ (a decrease of 17.42 ± 19.82%), which was statistically significant (p < 0.001).
The insertion of ADM after BCS is a safe and effective method for addressing volume defects, even though a slight reduction occurs in ADM volume.
保乳手术（BCS）的美容效果近来日益受到关注，外科医生正在探索使用脱细胞真皮基质（ADM）作为一种安全有效的乳房重建方法。本研究评估了在保乳手术后应用片状ADM进行乳房重建的乳腺癌患者的临床进展。
这项回顾性研究纳入了2019年10月至2021年10月期间在单一中心接受使用ADM的保乳手术的137例患者。手术过程中，将片状ADM折叠并插入切除后的缺损处。在直至2023年12月的监测随访期间评估并发症和癌症复发情况，并通过首次和末次随访计算机断层扫描（CT）的体积分析对插入的ADM的维持情况进行定量比较。
在137例接受评估的患者中，16例（11.6%）出现轻微并发症，17例（12.4%）在监测期内接受了活检。1例患者被诊断为复发。对55例患者测量了ADM体积。首次和末次CT扫描之间的平均体积减少为1.81±2.06 cm³（减少了17.42±19.82%），具有统计学意义（p<0.001）。
保乳手术后插入ADM是解决体积缺损的一种安全有效的方法，尽管ADM体积会有轻微减少。
