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Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation.

作者信息

Wei Zixian, Bao Liqing, Li Bowen, Yang Jinhua, Wang Jijiao, Xu Fangqi, Wenren Hubin, Zhang Kunyu, Shi Shang, Yan Liying, Tao Xin, Zhang Tianqi, Wang Zhiyue, Liu Yang

机构信息

Department of Hepatobiliary and Pancreatic Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

出版信息

Clin Transl Med. 2025 Mar;15(3):e70262. doi: 10.1002/ctm2.70262.

DOI:10.1002/ctm2.70262
PMID:40045503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12128141/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/f6c50f5e134d/CTM2-15-e70262-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/f43570d1c608/CTM2-15-e70262-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/b078033bc31e/CTM2-15-e70262-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/8cd4fe307591/CTM2-15-e70262-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/f6c50f5e134d/CTM2-15-e70262-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/f43570d1c608/CTM2-15-e70262-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/b078033bc31e/CTM2-15-e70262-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/8cd4fe307591/CTM2-15-e70262-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f73/12128141/f6c50f5e134d/CTM2-15-e70262-g001.jpg

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1
Fusobacterium nucleatum promotes anastomotic leakage by activating epithelial cells through the NOD1/RIPK2/ERK signalling pathway to drive IL-1β-induced neutrophil chemotaxis and collagen degradation.具核梭杆菌通过NOD1/RIPK2/ERK信号通路激活上皮细胞，以驱动IL-1β诱导的中性粒细胞趋化和胶原蛋白降解，从而促进吻合口漏。
Clin Transl Med. 2025 Mar;15(3):e70262. doi: 10.1002/ctm2.70262.
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本文引用的文献

1
induces colon anastomosis leak by activating epithelial cells to express MMP9.通过激活上皮细胞表达基质金属蛋白酶9（MMP9）来诱导结肠吻合口漏。
Front Microbiol. 2022 Dec 14;13:1031882. doi: 10.3389/fmicb.2022.1031882. eCollection 2022.
2
Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines.肠道微生物通过调节粘膜促炎细胞因子影响结直肠癌手术吻合口愈合。
Gut. 2023 Jun;72(6):1143-1154. doi: 10.1136/gutjnl-2022-328389. Epub 2022 Dec 30.
3
Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology.
基质金属蛋白酶：从分子机制到生理学、病理生理学和药理学。
Pharmacol Rev. 2022 Jul;74(3):712-768. doi: 10.1124/pharmrev.121.000349.
4
Anastomotic leak in colorectal cancer patients: New insights and perspectives.结直肠癌患者的吻合口漏：新的见解和观点。
Eur J Surg Oncol. 2020 Jun;46(6):943-954. doi: 10.1016/j.ejso.2020.02.027. Epub 2020 Feb 24.
5
The Neutrophil's Role During Health and Disease.中性粒细胞在健康和疾病中的作用。
Physiol Rev. 2019 Apr 1;99(2):1223-1248. doi: 10.1152/physrev.00012.2018.
6
The Microbiome-Host Interaction as a Potential Driver of Anastomotic Leak.微生物群-宿主相互作用作为吻合口漏的潜在驱动因素
Curr Gastroenterol Rep. 2019 Jan 26;21(1):4. doi: 10.1007/s11894-019-0668-7.
7
Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery.肠道微生物组对结直肠癌手术后吻合口漏和复发率的影响。
Br J Surg. 2018 Jan;105(2):e131-e141. doi: 10.1002/bjs.10760.
8
Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa.口服多磷酸盐可抑制黏质沙雷氏菌和铜绿假单胞菌胶原酶的产生，并预防吻合口漏。
Ann Surg. 2018 Jun;267(6):1112-1118. doi: 10.1097/SLA.0000000000002167.
9
A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery.结直肠手术中吻合口漏的当前概念与挑战的协作性综述
Colorectal Dis. 2017 Jan;19(1):O1-O12. doi: 10.1111/codi.13534.
10
Do we really know why colorectal anastomoses leak?我们真的知道为什么结直肠吻合口会漏吗？
J Gastrointest Surg. 2013 Sep;17(9):1698-707. doi: 10.1007/s11605-013-2227-0. Epub 2013 May 21.