小核仁RNA：癌症核糖体的隐藏前体
Small nucleolar RNAs: the hidden precursors of cancer ribosomes.
作者信息
Faucher-Giguère Laurence, de Préval Baudouin S, Rivera Andrea, Scott Michelle S, Elela Sherif Abou
机构信息
Department of Microbiology and Infectiology, University of Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
Department of Biochemistry and Functional Genomics, University of Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2025 Mar 6;380(1921):20230376. doi: 10.1098/rstb.2023.0376.
Ribosomes are heterogeneous in terms of their constituent proteins, structural RNAs and ribosomal RNA (rRNA) modifications, resulting in diverse potential translatomes. rRNA modifications, guided by small nucleolar RNAs (snoRNAs), enable fine-tuning of ribosome function and translation profiles. Recent studies have begun linking dysregulation of snoRNAs, via rRNA modifications, to tumourigenesis. Deciphering the specific contributions of individual rRNA modifications to cancer hallmarks and identifying snoRNAs with oncogenic potential could lead to novel therapeutic strategies. These strategies might target snoRNAs or exploit the dependence of cancer cells on specific rRNA modification sites, potentially disrupting aberrant ribosomal translation programs and hindering tumour growth. This review discusses current evidence and challenges in linking changes in snoRNA expression to rRNA modification and cancer biology.This article is part of the discussion meeting issue 'Ribosome diversity and its impact on protein synthesis, development and disease'.
核糖体在其组成蛋白质、结构RNA和核糖体RNA（rRNA）修饰方面存在异质性，从而产生了多样的潜在翻译组。由小核仁RNA（snoRNA）引导的rRNA修饰能够对核糖体功能和翻译谱进行微调。最近的研究已开始通过rRNA修饰将snoRNA的失调与肿瘤发生联系起来。解读单个rRNA修饰对癌症特征的具体贡献，并鉴定具有致癌潜力的snoRNA，可能会带来新的治疗策略。这些策略可能靶向snoRNA，或利用癌细胞对特定rRNA修饰位点的依赖性，有可能破坏异常的核糖体翻译程序并阻碍肿瘤生长。本综述讨论了将snoRNA表达变化与rRNA修饰及癌症生物学联系起来的当前证据和挑战。本文是“核糖体多样性及其对蛋白质合成、发育和疾病的影响”讨论会议特刊的一部分。
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