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Hepatocyte senescence and persistent liver injury in Fanconi anemia.

作者信息

Koo Jane, Snyder Alana J, Campbell Kathleen, Miller Erica, O'Conner Allison, Grompe Markus, Mehta Parinda A, Myers Kasiani C, Davies Stella M

机构信息

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH.

Department of Pediatrics, University of Cincinnati, Cincinnati OH; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA.

出版信息

Haematologica. 2025 Aug 1;110(8):1870-1874. doi: 10.3324/haematol.2024.287096. Epub 2025 Mar 6.

DOI:10.3324/haematol.2024.287096
PMID:40045901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12358771/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/12358771/2a5f534fb9f3/1101870.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/12358771/238b21cb1b54/1101870.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/12358771/2a5f534fb9f3/1101870.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/12358771/238b21cb1b54/1101870.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db94/12358771/2a5f534fb9f3/1101870.fig2.jpg

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本文引用的文献

1
Cell senescence in liver diseases: pathological mechanism and theranostic opportunity.肝脏疾病中的细胞衰老：病理机制与治疗机遇。
Nat Rev Gastroenterol Hepatol. 2024 Jul;21(7):477-492. doi: 10.1038/s41575-024-00913-4. Epub 2024 Mar 14.
2
Liver abnormalities are frequent and persistent in patients with Fanconi anemia.肝异常在范可尼贫血患者中频繁且持续存在。
Blood Adv. 2024 Mar 26;8(6):1427-1438. doi: 10.1182/bloodadvances.2023012215.
3
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases.
肝脏纤维化中的细胞衰老：与年龄相关的慢性肝病的关系。
Expert Opin Ther Targets. 2021 Sep;25(9):799-813. doi: 10.1080/14728222.2021.1992385. Epub 2021 Oct 22.
4
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives.肝星状细胞衰老在肝纤维化中的作用：特征、机制及展望。
Mech Ageing Dev. 2021 Oct;199:111572. doi: 10.1016/j.mad.2021.111572. Epub 2021 Sep 16.
5
A proteomic atlas of senescence-associated secretomes for aging biomarker development.衰老相关分泌表型的蛋白质组学图谱用于衰老生物标志物的开发。
PLoS Biol. 2020 Jan 16;18(1):e3000599. doi: 10.1371/journal.pbio.3000599. eCollection 2020 Jan.
6
Serum amyloid A levels in patients with liver diseases.肝脏疾病患者的血清淀粉样蛋白 A 水平。
World J Gastroenterol. 2019 Nov 21;25(43):6440-6450. doi: 10.3748/wjg.v25.i43.6440.
7
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.槲皮素通过抑制肝星状细胞活化和减少自噬，通过 TGF-β1/Smads 和 PI3K/Akt 途径预防肝纤维化。
Sci Rep. 2017 Aug 24;7(1):9289. doi: 10.1038/s41598-017-09673-5.
8
Cellular senescence drives age-dependent hepatic steatosis.细胞衰老导致与年龄相关的肝脂肪变性。
Nat Commun. 2017 Jun 13;8:15691. doi: 10.1038/ncomms15691.
9
Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study.范可尼贫血患者的无辐射、替代供体造血细胞移植：一项前瞻性多机构研究的结果
Blood. 2017 Apr 20;129(16):2308-2315. doi: 10.1182/blood-2016-09-743112. Epub 2017 Feb 8.
10
Senescence in chronic liver disease: Is the future in aging?慢性肝病中的衰老：未来在于衰老吗？
J Hepatol. 2016 Oct;65(4):825-834. doi: 10.1016/j.jhep.2016.05.030. Epub 2016 May 28.