Rangel-Guerra R, Martínez H R, Sáenz C
Arch Neurol. 1985 Jun;42(6):578-81. doi: 10.1001/archneur.1985.04060060080013.
Mucormycosis is fulminant fungal infection that usually occurs in debilitated patients with an underlying pathologic condition. The common clinical types include rhinocerebral, pulmonary, disseminated, and intestinal forms. This report describes 11 cases seen in our institution since 1970. Of nine patients with underlying diabetes mellitus, eight developed rhinocerebral mucormycosis and one had the cutaneous form. Two additional patients with acute leukemia showed the disseminated and pulmonary forms of mucormycosis. In nine patients, the diagnosis was established by histologic appearance and by culture of infected tissue obtained by biopsy. In two patients the diagnosis was made during postmortem examination. Five patients survived. We have emphasized the importance of early diagnosis and prompt, appropriate medical and surgical therapy to obtain a significant survival rate in patients with this frequently fatal disease.
毛霉病是一种暴发性真菌感染，通常发生在患有基础病理状况的虚弱患者中。常见的临床类型包括鼻脑型、肺型、播散型和肠型。本报告描述了自1970年以来在我们机构中见到的11例病例。在9例患有基础糖尿病的患者中，8例发生了鼻脑型毛霉病，1例为皮肤型。另外2例急性白血病患者表现为毛霉病的播散型和肺型。9例患者通过组织学表现和活检获得的感染组织培养确诊。2例患者在尸检时确诊。5例患者存活。我们强调了早期诊断以及及时、恰当的药物和手术治疗对于这种常致命疾病患者获得显著生存率的重要性。
