儿童群体中全身免疫炎症指数与中心性肥胖的关联：一项横断面和队列研究。
Association between systemic immune-inflammation index and central obesity in pediatric populations: a cross-sectional and cohort study.
作者信息
Zhang Qian, Kong Bingxuan, Zhou Zhiyu, Liu Fangqu, Wen Erya, Lin Bingliang, Xuan Peng, Lu Wenlong, Su Zhe, Li Yanyan, Tang Yuhan, Xiong Jingfan, Yao Ping, Li Yan
机构信息
Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China.
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
出版信息
Front Immunol. 2025 Feb 19;16:1546612. doi: 10.3389/fimmu.2025.1546612. eCollection 2025.
BACKGROUND
Central obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated in the pathophysiology of obesity-related chronic inflammation. Despite its potential relevance, the specific relationship between central obesity and SII in the pediatric population remains insufficiently explored. The objective of this study was to examine the relationship between SII and central obesity, with a particular focus on the potential of SII as a predictor of central obesity and a means of preventing obesity at an early stage of life.
METHODS
Waist-to-height ratio (WHtR), subcutaneous fat, and visceral fat were employed as obesity proxies. Central obesity was defined according to WHtR with a cutoff value of 0.46. The implications of SII on central obesity were examined in a sample of 4,730 individuals in 2021 and validated through a prospective study involving 1,425 subjects in 2023. Cross-sectional associations between SII and central obesity were examined using binomial logistic regression models and generalized linear models. The restricted cubic spline regression was used to explore the non-linear relationship between SII and obesity indicators. In a prospective study, we employed a modified Poisson regression model to investigate the potential causal relationship between SII and central obesity.
RESULTS
Cross-sectionally, adolescents in the highest quartile of SII levels exhibited the greatest risk for central obesity(OR=3.07, 95% CI:2.453.87) when compared to those in the lowest quartile. Subgroup analyses showed that higher SII was associated with central obesity. Longitudinally, individuals in the highest SII quartile were found to have the highest risk of developing central obesity (RR=1.83, 95% CI:1.182.83) over time.
背景
儿童中心性肥胖是一个重大的公共卫生问题，因为它与代谢和心血管疾病风险升高密切相关。全身免疫炎症指数（SII）与肥胖相关的慢性炎症的病理生理学有关。尽管其具有潜在相关性，但儿童人群中中心性肥胖与SII之间的具体关系仍未得到充分探索。本研究的目的是探讨SII与中心性肥胖之间的关系，特别关注SII作为中心性肥胖预测指标的潜力以及在生命早期预防肥胖的手段。
方法
采用腰高比（WHtR）、皮下脂肪和内脏脂肪作为肥胖指标。中心性肥胖根据WHtR定义，临界值为0.46。2021年在4730名个体样本中研究了SII对中心性肥胖的影响，并于2023年通过一项涉及1425名受试者的前瞻性研究进行验证。使用二项逻辑回归模型和广义线性模型研究SII与中心性肥胖之间的横断面关联。采用受限立方样条回归探索SII与肥胖指标之间的非线性关系。在前瞻性研究中，我们采用修正的泊松回归模型研究SII与中心性肥胖之间的潜在因果关系。
结果
横断面研究中，与SII水平最低四分位数的青少年相比，SII水平最高四分位数的青少年中心性肥胖风险最高（OR=3.07，95%CI：2.453.87）。亚组分析表明，较高的SII与中心性肥胖相关。纵向研究发现，SII四分位数最高的个体随着时间推移发生中心性肥胖的风险最高（RR=1.83，95%CI：1.182.83）。
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